ID A0A493U1S3_ANAPP Unreviewed; 569 AA.
AC A0A493U1S3;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Interleukin 1 receptor accessory protein {ECO:0000313|Ensembl:ENSAPLP00000032066.1};
GN Name=IL1RAP {ECO:0000313|Ensembl:ENSAPLP00000032066.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000032066.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000032066.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000032066.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR AlphaFoldDB; A0A493U1S3; -.
DR Ensembl; ENSAPLT00000036073.1; ENSAPLP00000032066.1; ENSAPLG00000016792.1.
DR GeneTree; ENSGT01090000260076; -.
DR Proteomes; UP000016666; Chromosome 9.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR CDD; cd20992; Ig1_IL1R_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR041416; IL-1RAcP-like_ig.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890:SF20; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; 1.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF18452; Ig_6; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01536; INTRLKN1R12F.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 37..124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 276..429
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 438..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 63784 MW; 5A2C9F2588011B21 CRC64;
LRDGWYLRAS SGTLFFLLAE RCDDWGVDTM KQIQIYDGEP AKIKCPLFET FLKYNYSTAH
SAGLTLIWYR IGQDRDLEEP INFRLPDNRI SKEKDTLWFW PALLNDTGNY TCMLRNTTYC
SKVAFPLEVV PKDQDSCVSH SIKPTEQKFY LEHANEKIIC PDIDGFFPAS VTPTVKWYQL
VDGFNNRYPQ GPKLVISIVR SAYEGNYTCI VTFKDHGRTY NLTRTVMMKV VGSPNKALPP
QFTSPNEKVI YELEAGKLQR MPAGMGRHGQ LGTEALLFSC FPSASPRQAL KLLPSLGREG
VCLCRFAIKQ LPLAFLSLLP HPCAPQFLTL VLLDTTEAVF DFIQRSRRMI VVLSPDYLTE
KSISLLEFKL GIMCQNAIAT KLIVVEYRPL QCTHPSILQL KESVSFVTWK GEKSKRSGSH
FWKALRLALP LRSLSAGSGW NESCSSQSDI SPDPVQRRRS RLKGRPEPPG IAATGIAPRG
TAAASTPKAK HRAKHFLACR CCGTYCDGGS RLKRKHRAVA EPWWETQLCK PGAQGGPGSS
RPEPPPSQAP ALALCQYSDL SNNNDFYVL
//
