ID A0A493U2H7_ANAPP Unreviewed; 563 AA.
AC A0A493U2H7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 24 member 4 {ECO:0000313|Ensembl:ENSAPLP00000032323.1};
GN Name=SLC24A4 {ECO:0000313|Ensembl:ENSAPLP00000032323.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000032323.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000032323.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000032323.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR AlphaFoldDB; A0A493U2H7; -.
DR STRING; 8840.ENSAPLP00000032323; -.
DR Ensembl; ENSAPLT00000017489.1; ENSAPLP00000032323.1; ENSAPLG00000006958.2.
DR GeneTree; ENSGT01030000234532; -.
DR Proteomes; UP000016666; Chromosome 5.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0120199; C:cone photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0008273; F:calcium, potassium:sodium antiporter activity; IEA:Ensembl.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:1990034; P:calcium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0071486; P:cellular response to high light intensity; IEA:Ensembl.
DR GO; GO:0036368; P:cone photoresponse recovery; IEA:Ensembl.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IEA:Ensembl.
DR GO; GO:0042756; P:drinking behavior; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0086009; P:membrane repolarization; IEA:Ensembl.
DR GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0021630; P:olfactory nerve maturation; IEA:Ensembl.
DR GO; GO:0007602; P:phototransduction; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1903998; P:regulation of eating behavior; IEA:Ensembl.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1990680; P:response to melanocyte-stimulating hormone; IEA:Ensembl.
DR GO; GO:1990834; P:response to odorant; IEA:Ensembl.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF21; SODIUM_POTASSIUM_CALCIUM EXCHANGER 4; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..175
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 364..527
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 563 AA; 63066 MW; 3F4F09086E40E788 CRC64;
MERSKVENSP AINEFPEDVF TNKERQQGGV LLHIIAALYM FYALAIVCDD FFVPSLEKIC
EKLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN ILCIVGVCGL
FAGQVVCLTQ WAVFRDSVYY TLSVIVLIVF IYDEKIEWWE SLILIIMYSF YILIMKYNVR
MQNFFTLKSK NVGNGDTVNN ELEDGNKYYA SSYDDPSIPL LCKVKGMQQY GKNSVVMVDE
IICSSPPKYR FPEAGLRIMI TNKFGPRTRM RMASRLIINE RQRLIQSANG SGKPLQNGRH
ENIENGNIPV VNQEEESEQD NLSPFSLPDG KMNKVKWILT WPLIFLLFCT IPNCSKPRWE
SWFMFTFVLS TLWIALFSYF MVWMENIVKK QPACFVLRLC IHVTVIGYTL GIPDVIMGIT
FLAAGTSVPD CMASLIVARQ GLGDMAVSNT IGSNVFDILV GLGVPWGLQT MAIDCGSTVK
INSKGLVYSV ALLLGSVALT VSIRVSKCYS SEYSDCKIII NYLLYIIWKE NFKVLIIPKV
SIFMCHSYNS TMSRRASIVL CED
//
