ID A0A494BBF9_MOUSE Unreviewed; 213 AA.
AC A0A494BBF9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Leucyl-tRNA synthetase {ECO:0000313|Ensembl:ENSMUSP00000158450.2};
DE Flags: Fragment;
GN Name=Lars1 {ECO:0000313|Ensembl:ENSMUSP00000158450.2,
GN ECO:0000313|MGI:MGI:1913808};
GN Synonyms=Lars {ECO:0000313|MGI:MGI:1913808};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000158450.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000158450.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000158450.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000158450.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000158450.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363039}.
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DR jPOST; A0A494BBF9; -.
DR Antibodypedia; 45640; 154 antibodies from 31 providers.
DR Ensembl; ENSMUST00000237587.2; ENSMUSP00000158450.2; ENSMUSG00000024493.10.
DR AGR; MGI:1913808; -.
DR MGI; MGI:1913808; Lars1.
DR VEuPathDB; HostDB:ENSMUSG00000024493; -.
DR GeneTree; ENSGT00390000012163; -.
DR ChiTaRS; Lars; mouse.
DR Proteomes; UP000000589; Chromosome 18.
DR Bgee; ENSMUSG00000024493; Expressed in floor plate of midbrain and 294 other cell types or tissues.
DR ExpressionAtlas; A0A494BBF9; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 1: Evidence at protein level;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Proteomics identification {ECO:0007829|EPD:A0A494BBF9,
KW ECO:0007829|MaxQB:A0A494BBF9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 44..142
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000158450.2"
SQ SEQUENCE 213 AA; 24322 MW; 2818DFCF6314F69A CRC64;
XGQAESPLGI RPQQMTKDVW DYVFFKDAPF PKTQIPKEKL DQLKQEFEFW YPVDLRASGK
DLIPNHLSYY IYNHVAMWPE QSDKWPVSVR ANGHLLLNSE KMSKSTGNFL TLSQAVDKFS
ADGMRLALAD AGDTVEDANF VEAMADAGIL RLYTWVEWVK EMLASCSSLR SGPADSFNDR
VFARLRKTNT VNWPRRACTE SLCSALLKFR QSF
//
