ID A0A494C1F5_HUMAN Unreviewed; 624 AA.
AC A0A494C1F5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Pro-neuregulin-1, membrane-bound isoform {ECO:0000256|ARBA:ARBA00034341};
DE Flags: Fragment;
GN Name=NRG1 {ECO:0000313|Ensembl:ENSP00000499045.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000499045.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000499045.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000499045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the neuregulin family.
CC {ECO:0000256|ARBA:ARBA00008216}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC021909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC023948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC068931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001153471.1; NM_001159999.2.
DR AlphaFoldDB; A0A494C1F5; -.
DR SMR; A0A494C1F5; -.
DR MassIVE; A0A494C1F5; -.
DR PeptideAtlas; A0A494C1F5; -.
DR Antibodypedia; 3706; 1142 antibodies from 46 providers.
DR DNASU; 3084; -.
DR Ensembl; ENST00000650866.1; ENSP00000499045.1; ENSG00000157168.22.
DR GeneID; 3084; -.
DR CTD; 3084; -.
DR HGNC; HGNC:7997; NRG1.
DR VEuPathDB; HostDB:ENSG00000157168; -.
DR GeneTree; ENSGT00940000157326; -.
DR OrthoDB; 3025258at2759; -.
DR ChiTaRS; NRG1; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000157168; Expressed in ventricular zone and 142 other cell types or tissues.
DR ExpressionAtlas; A0A494C1F5; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR CDD; cd00053; EGF; 1.
DR CDD; cd05895; Ig_Pro_neuregulin-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR040180; Neuregulin.
DR InterPro; IPR002154; Neuregulin_C.
DR InterPro; IPR018250; NRG1.
DR PANTHER; PTHR11100; HEREGULIN-NEUREGULIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11100:SF7; PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF02158; Neuregulin; 1.
DR PRINTS; PR01089; NEUREGULIN.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:A0A494C1F5,
KW ECO:0007829|MaxQB:A0A494C1F5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..107
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 157..201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 624
FT /evidence="ECO:0000313|Ensembl:ENSP00000499045.1"
SQ SEQUENCE 624 AA; 68888 MW; 0AA7C095D1B3BC39 CRC64;
MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA
STEGAYVSSE SPIRISVSTE GANTSSSTST STTGTSHLVK CAEKEKTFCV NGGECFMVKD
LSNPSRYLCK CPNEFTGDRC QNYVMASFYK HLGIEFMEAE ELYQKRVLTI TGICIALLVV
GIMCVVAYCK TKKQRKKLHD RLRQSLRSER NNMMNIANGP HHPNPPPENV QLVNQYVSKN
VISSEHIVER EAETSFSTSH YTSTAHHSTT VTQTPSHSWS NGHTESILSE SHSVIVMSSV
ENSRHSSPTG GPRGRLNGTG GPRECNSFLR HARETPDSYR DSPHSERYVS AMTTPARMSP
VDFHTPSSPK SPPSEMSPPV SSMTVSMPSM AVSPFMEEER PLLLVTPPRL REKKFDHHPQ
QFSSFHHNPA HDSNSLPASP LRIVEDEEYE TTQEYEPAQE PVKKLANSRR AKRTKPNGHI
ANRLEVDSNT SSQSSNSESE TEDERVGEDT PFLGIQNPLA ASLEATPAFR LADSRTNPAG
RFSTQEEIQA RLSSVIANQD PIAV
//
