ID A0A494YXU6_9BACI Unreviewed; 795 AA.
AC A0A494YXU6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:RKQ14990.1};
GN ORFNames=D8M05_11050 {ECO:0000313|EMBL:RKQ14990.1};
OS Oceanobacillus bengalensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=1435466 {ECO:0000313|EMBL:RKQ14990.1, ECO:0000313|Proteomes:UP000281813};
RN [1] {ECO:0000313|EMBL:RKQ14990.1, ECO:0000313|Proteomes:UP000281813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCCC 1K00260 {ECO:0000313|EMBL:RKQ14990.1,
RC ECO:0000313|Proteomes:UP000281813};
RX PubMed=26303283; DOI=10.1007/s10482-015-0573-5;
RA Yongchang O., Xiang W., Wang G.;
RT "Oceanobacillus bengalensis sp. nov., a bacterium isolated from seawater of
RT the Bay of Bengal.";
RL Antonie Van Leeuwenhoek 108:1189-1196(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKQ14990.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RBZO01000016; RKQ14990.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A494YXU6; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000281813; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000281813}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..305
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 795 AA; 87523 MW; 7C4A50928433E863 CRC64;
MVYQVKKAAV LGTGVMGSAI AAHLANIGIN VLMLDITPKQ LTKEEEKKGL TLDHPMVRNR
IAQASKKALL KQKPSPITTK KSLDLIKVGN MDDDMEKLSD VDWIIEVVVE NLEIKKKVFE
NIDKHRKAGS IVSSNTSGIS VNDMVENCSD DLKKHFLGTH FFNPPRYLKL LEIIPTKYTD
EAVLSFMKTF GENVLGKGVV EAKDTPNFIA NRIGTYGLLV TVREMLKGGY SVGEVDSVTG
PMIGRPKSAT FRTLDVVGID TFIHVAKNVY DQVDGEEKTV FDVPEFINRM NENGWIGAKA
KQGFFVKKDR EIYEINPETL EYVERKKLKT AATEIVKQQK GTRNKLKALV SAKGDRAGDL
VWSVLKPVLL YSAELLGKIA DDIVSIDQAM KWGFGWELGP FESWDAIGLR ASISRMQEEG
ETVPKWILNL LEDGYESFYN KEAGDISYYD QGDYKAQQFN ENEINLKLLK EKNGIIKKNT
GASLIDIGDG VALLEFHSKS NALGLDTIQM VQFAIEEVEN NYEGLVIGNQ GKNFSVGANI
ALMLMEAQDE NFDELDLVIR QFQNMAMKIK YAEKPVVSAP FNMTVGGGAE VSLPAAAIQA
SAETYIGLVE VGVGLIPGGG GTKELYLKQL RNMPKGIKFD LSKVANDVFE KIATAKVSTS
AAEAVENGFL GHGDSISVNP DHLISDAKAK VLALRKAGYR KPIHEKIPVV GEAGYAAMLM
GAKSLQYGGY ASEHDIKIAE KLAYVLSGGR IREGSVIDEQ IMLDLEREAF LSLIGEPLTQ
ARMQHMLLKG KALRN
//
