ID A0A495EDV3_9FLAO Unreviewed; 873 AA.
AC A0A495EDV3;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=CLV91_0146 {ECO:0000313|EMBL:RKR14077.1};
OS Maribacter vaceletii.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Maribacter.
OX NCBI_TaxID=1206816 {ECO:0000313|EMBL:RKR14077.1, ECO:0000313|Proteomes:UP000269412};
RN [1] {ECO:0000313|EMBL:RKR14077.1, ECO:0000313|Proteomes:UP000269412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25230 {ECO:0000313|EMBL:RKR14077.1,
RC ECO:0000313|Proteomes:UP000269412};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKR14077.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RBIQ01000007; RKR14077.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A495EDV3; -.
DR Proteomes; UP000269412; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000269412}.
FT DOMAIN 693..709
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 619..626
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 873 AA; 98940 MW; 306724850E83D836 CRC64;
MAAKEKTKKV TPLMQQYNTI KTKYPDAMLL FRVGDFYETF GEDAIKASKI LGITLTNRNN
GGEKTELAGF PHHSVNTYLP KLVKAGQRVA ICDQLEDPKQ TKTIVKRGVT ELVTPGVALN
DDILNAKTNN FLCAVHFGRK KLGVAFVDIS TGEFLTSEGN EEQIDKLLQN FAPNEILISK
AHKKEFLDVF GTQFHTFFME DWVFQEDYTK ETLTNHFKTN TLKGFGVDHL INGTIASGVV
LHYLSETQHN QLQHINKLQR IAEDEYIWMD RFTIKNLELY HSHNTNAVTL LDVIDKTISP
MGGRMIKRWL ALPLKNLERI QKRHAVITYL SKQEEDLDKL QHWIKQMGDL ERLISKVSTG
KVNPREIIQL KNSLEAIIPL KQLTKNAKNE ALNLIGDQLH GCDLLRSKIK EMLSEEAPVN
ILKGNAIAKG YSEELDELRG LAFSGKEYLD NMLTRETERT GISSLKIASN NVFGYYIEVR
NTHKDKVPEE WIRKQTLVNA ERYITEELKE YEAKILGAEE RILSLEQQLF SQLVVWMQEY
IAPVQNNAQL IAQLDCLCGF TQLSKENNYV LPEVNESTDL SITNGRHPVI EKQLPLGETY
IANDVYLDRT QQQIIMITGP NMSGKSAILR QTALIVLLAQ MGSFVPAKAA TIGMVDKIFT
RVGASDNISM GESTFMVEMN ETASILNNLS ERSLVLLDEI GRGTSTYDGI SIAWAISEYL
HEHPAKAKTL FATHYHELNE MCNTFERIKN YNVSVKELKD TVLFLRKLTP GGSEHSFGIH
VAKMAGMPQQ VISKANKILK KLEKSHSSEE LTNKLQSAQN EMQLSFFNLD DPLLEQIKEE
ITHLDIDTLT PVEALMKLNE IKRLLVKKKK ATS
//
