ID A0A495JGW1_9ACTN Unreviewed; 658 AA.
AC A0A495JGW1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:RKR88025.1};
GN ORFNames=BDK92_2329 {ECO:0000313|EMBL:RKR88025.1};
OS Micromonospora pisi.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=589240 {ECO:0000313|EMBL:RKR88025.1, ECO:0000313|Proteomes:UP000277671};
RN [1] {ECO:0000313|EMBL:RKR88025.1, ECO:0000313|Proteomes:UP000277671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45175 {ECO:0000313|EMBL:RKR88025.1,
RC ECO:0000313|Proteomes:UP000277671};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKR88025.1}.
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DR EMBL; RBKT01000001; RKR88025.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A495JGW1; -.
DR Proteomes; UP000277671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:RKR88025.1};
KW Cell division {ECO:0000313|EMBL:RKR88025.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000277671}.
FT DOMAIN 45..157
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 164..337
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 379..652
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 658 AA; 69965 MW; CA34B95BCDB184E7 CRC64;
MRPHEHHRND NLSRRRRLRR PMLAAFTGLG LVATLLTGCS REAPAEQAVD EFLRGWQEGK
LDQVRFVDGQ GQQITGPKVV EEIAFLRGDL PAPAVRREGE ASVGGDAATA KLTVDWTLPG
GTHWAYPTTV RLKRDTEDRW RIIWEPRIAH EQLTEGDQLT VRRVSATRGA ILDGAGAPIV
TTRPIVVVGV QPSEVTDVPA LVKQLEAAFK AIRPAISPPI ELGDLPDRMK QAKPDAFVEV
VSLRKEAYQQ IKPRIYDLPG TKFREEQREL APTREFARAL LGSVDPVQKD DLDANPGVYV
ESDLVGHGGL QGQYEKQLRG TPANTVVISR RNADGKIEPT DTELFRTEPT PGAPLRTTID
VKTQNAADAA LAPDPHRTAM VAIRISDGSV LATANGPGGG AENLALTAQV PPGSTFKMVS
TLGLLDGGAV SLDAPVSCPK TFTVDGRSFK NSNDFELGNV PFRTDFAKSC NTAFAALAPK
LGDTGLADAG RSLGLEAKWE LGVEAFTGKV STGGSPAERA AAAFGQGTTL VSPIAMAAAT
AAVAKGQWQQ PKLVLDPAPA APAPAGPPLK TTSVEPLRTM MREVVTVGSA TALKTVPGGP
VQGKTGTAEY DDNPAHTHAW FVGWQGDVAF AVFVENGGGS GETAVPIAER FLRNLAAR
//
