ID   A0A495PUM7_9FLAO        Unreviewed;       258 AA.
AC   A0A495PUM7;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   13-SEP-2023, entry version 8.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   ORFNames=BC962_2194 {ECO:0000313|EMBL:RKS53927.1};
OS   Gillisia mitskevichiae.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Gillisia.
OX   NCBI_TaxID=270921 {ECO:0000313|EMBL:RKS53927.1, ECO:0000313|Proteomes:UP000276282};
RN   [1] {ECO:0000313|EMBL:RKS53927.1, ECO:0000313|Proteomes:UP000276282}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19839 {ECO:0000313|EMBL:RKS53927.1,
RC   ECO:0000313|Proteomes:UP000276282};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RKS53927.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RBLG01000002; RKS53927.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A495PUM7; -.
DR   OrthoDB; 9795084at2; -.
DR   Proteomes; UP000276282; Unassembled WGS sequence.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   NCBIfam; TIGR02772; Ku_bact; 1.
DR   PANTHER; PTHR41251; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   PANTHER; PTHR41251:SF1; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SPOC domain-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_01875}.
FT   DOMAIN          52..179
FT                   /note="Ku"
FT                   /evidence="ECO:0000259|SMART:SM00559"
SQ   SEQUENCE   258 AA;  29903 MW;  C26791C93B6FD130 CRC64;
     MRSIWNGSIS FGLVSIPIKL YSGSEDRKLD LDMLDRHDNA RIRYKRVNED TGKEVEWKDI
     VKGFKKDESY IVLEKEDFEQ ANLKKSKTID IEEFINEADV ADVLFKKPYF LEPQKEGGKS
     YNLLRDALKK TKKVGVATFV MRQKEHLSLI GIYKNALVLH VIRFDDEIRD PSELKLPSTK
     ISKKEVDMAI NLIDQYTDKF DLEKYKDVYN EQLMKIIDSK STGKVKKPEK FESKPTPAKD
     LMAQLKASLE KKKKSKAS
//