ID A0A495VYF0_9PSEU Unreviewed; 973 AA.
AC A0A495VYF0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 28-JUN-2023, entry version 15.
DE SubName: Full=Ketoacyl-synthetase-like protein {ECO:0000313|EMBL:RKT53613.1};
GN ORFNames=C8E97_2185 {ECO:0000313|EMBL:RKT53613.1};
OS Saccharothrix australiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=2072 {ECO:0000313|EMBL:RKT53613.1, ECO:0000313|Proteomes:UP000282084};
RN [1] {ECO:0000313|EMBL:RKT53613.1, ECO:0000313|Proteomes:UP000282084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43800 {ECO:0000313|EMBL:RKT53613.1,
RC ECO:0000313|Proteomes:UP000282084};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKT53613.1}.
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DR EMBL; RBXO01000001; RKT53613.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A495VYF0; -.
DR OrthoDB; 3651481at2; -.
DR Proteomes; UP000282084; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000282084};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 6..429
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 598..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 973 AA; 101453 MW; 7E197767F9F0AE40 CRC64;
MTRGNDEPIA VVGAGCRFPR VRGPLALWRA LCDGVDVVGP IGADRYGLRA LAGTDEGSRH
RPAPRMASIE DVSSFDADFF GIGRRQAAHM DPQQRLVLET TWEAFEDAGV VTGGTATRRT
GVFMAKAASH YWHLLARDGL LDMFSVIGAA GSAGLSGQVS FQFDLRGPSM TVDTNCSGGL
AAVHLACRSL RDGECRLAVA GAVHLVLSPE ETIAYGRAGV LSAKGRSAFA DAGADGFVRG
EGCAVVVLKP LSAARRDGDR VYAVVLGSAV TNDGRASPTM LAPAAATQEE VLRLAYRDAG
VEPARVSFVE THGVGTPAGD PVEIAALASV LGPGRPPGRP VLLSSVRGNF GHQEPVAGLT
GLLKAALALH HRLLPATLHH TTPTPALRWD GSRCSVVTRS TPLPDRDGLV AGVNSFSVTG
TNVHAVLGSA DHPVPGGAPD VGPFALVLSA RHPDSLDAAA AAHAEFLETS PEVPLADVCH
TAAVRRAHHP YRRAFRAHDR AGMVEALRRE PRPLRATPVG SPPGVVLVLR DEPTDHAVVE
ELSRRSNAFR DAVRECAASP RRAAGPLHPT APDLASRPLP AGLIALWRDW GVRLTTPPGS
VAARRPGDGV DADRAAEPRL PPVTRVDAPG AAASDDLVLH LTPAGVFLGD PPAAGCAGSV
WESLVAAAAD LYEAGHALRW ERILPAGRQV SLPPYPWRRR RYWAPTTGAP AERAHPLLPD
HATEERGVRW RTTATPRGGA GDRGTSGAPT AGGLVELAAA VAHRLCGSAP ATVEDLSVVL
DPAFRHGSAL EAAGVAGPPG RWRFHITEAP GADRPAARAR LAEGTARVSR RREAGDLPAL
LRHRVQRTGG GAARPRGPAA DPRSPGVRVA ERHGNSVLLR LTGPAPGEVD FGFPPDLLDG
VLGAATGRHA ADAVLTVERT TVVGRWTSSM WGLVTGTPQG GPADVLVCDD DGAVLVELGG
VRWAPSPLRA CTP
//
