ID   A0A495W8P4_9PSEU        Unreviewed;      1039 AA.
AC   A0A495W8P4;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Amino acid adenylation domain-containing protein/thioester reductase-like protein {ECO:0000313|EMBL:RKT56138.1};
GN   ORFNames=C8E97_4827 {ECO:0000313|EMBL:RKT56138.1};
OS   Saccharothrix australiensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharothrix.
OX   NCBI_TaxID=2072 {ECO:0000313|EMBL:RKT56138.1, ECO:0000313|Proteomes:UP000282084};
RN   [1] {ECO:0000313|EMBL:RKT56138.1, ECO:0000313|Proteomes:UP000282084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43800 {ECO:0000313|EMBL:RKT56138.1,
RC   ECO:0000313|Proteomes:UP000282084};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RKT56138.1}.
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DR   EMBL; RBXO01000001; RKT56138.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A495W8P4; -.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000282084; Unassembled WGS sequence.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd05235; SDR_e1; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR010080; Thioester_reductase-like_dom.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   NCBIfam; TIGR01746; Thioester-redct; 1.
DR   PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282084}.
FT   DOMAIN          530..609
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1039 AA;  110117 MW;  4221E7ECC629C6B7 CRC64;
     MEPPEAAVVA TDRGAARTAA SGPATDTVHG LFDARAAAAP DATAATHGGR RLSYGEVRRR
     SDALAARLCR SGVVRGDRVG VVGARGLDAP VAFLGVLKAG AAYVPLDDTA PPARQQAMAD
     DAGVHTVVTL PGSTCRVRRL RTRVPVDEAR PDPPAEAVRP PGVTADDCAY VMFTSGSTGR
     PKPVAVPHRG VVALARSDLV GQRPRPGDRV LHGYALSSDA STIEVWPPLL NGACLVPVDR
     ADLLSPDALE RVLRAEGVAI AYLTTGVFHH VARVRPAALR ALRFVSAGGE AMDPELARTV
     LSACPGTAVV NFYGPTENTV VTTAYDVRRL PADATAVPIG RPLEHCSCHV VRADGTPAGV
     GEEGDLLVGG AGLALGYLGD PALTGRRFRS SPVEPGAVLY DTGDRVVRLA TGDLEYRGRA
     DRQVKLRGHR IELDGVEARI RAHADVGEAV VELSGGTLVG YVTPARPGAG VRVDLVRRDL
     ATWLPPSAVP SRLVELPAFP VNGAGKVDRG RLRALLADRP AAVPATVPAP RGDGPRETVT
     AVWQAVLRVP VGEADDFFAL GGDSLLAAEV VNRTLTAFGV DARHGSALIR ELLDDPTPAG
     FTAAVRRAVE RPRTPDRAGP AVDFTAEAEL GFRLPRRQGP PPRVHDPRHV LLTGASGFIG
     AFLLDRLLRR TGAEVHCPVR ARDRGHATRR VRANLARYGL GGDHAADRVT CFPADLGRPL
     LGLDARHAAD LARRLDLVVH AGARVNFLYP YRALRSVNVD GTREVVRLAA PRRVPVHFLS
     TIAVVAGFGT AGVRHVAEDR PLDHADRLTM GYAESKWVAE RLLRDAADQG LPVAVYRPYE
     VTGDQAGGEC NTETAICSLI RVVADTGLAP DIPLPLDFVP VDHVSDAIVH IATSGTPDHR
     TYHLTNPRPA TFADLLDRMR AAGYDITTLP YPEWVGELVR HVEADPTSPT APFVPLCVDR
     GHKADISVKE MYFEGTFPVL GRSAVEAALA DSGLRCPPVD DELLDRYLDY FFASGYLTRP
     DGGAVRGTAA AGDAVGGTR
//