UniProt: A0A495X852

Database: UniProt
Entry: A0A495X852_9PSEU

LinkDB:  A0A495X852_9PSEU 
Original site:  A0A495X852_9PSEU

All links

Ontology (5)   
   GO (5)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (45)   
   InterPro (24)   
   Pfam (11)   
   PROSITE (3)   
   SMART (7)   
All databases (51)   

Download RDF

ID   A0A495X852_9PSEU        Unreviewed;      3515 AA.
AC   A0A495X852;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Type I polyketide synthase PikAII {ECO:0000313|EMBL:RKT70182.1};
GN   ORFNames=DFJ66_3431 {ECO:0000313|EMBL:RKT70182.1};
OS   Saccharothrix variisporea.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharothrix.
OX   NCBI_TaxID=543527 {ECO:0000313|EMBL:RKT70182.1, ECO:0000313|Proteomes:UP000272729};
RN   [1] {ECO:0000313|EMBL:RKT70182.1, ECO:0000313|Proteomes:UP000272729}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43911 {ECO:0000313|EMBL:RKT70182.1,
RC   ECO:0000313|Proteomes:UP000272729};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RKT70182.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RBXR01000001; RKT70182.1; -; Genomic_DNA.
DR   Proteomes; UP000272729; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 3.40.50.11460; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
PE   4: Predicted;
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272729};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          33..443
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1326..1401
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1413..1836
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3356..3431
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3515 AA;  369419 MW;  A9A7724A73203136 CRC64;
     MANEDKLRDY LKRVTVDLQK TRQRLHDVEA AAHEPIAIVG MACRYPGGVT GPEDLWRLVA
     SGTDATGAFP TDRGWDLAAL HDPESQREDT SYTARGGFLY DAADFDPAFF GISPREAVRL
     DPQQRLLLEV AWESLERAGI DPASLAGSPT GVFTGLMYHD YAGSNSSGSV VSGRVAYTLG
     LEGPAVTVDT ACSSSLVALH LAIQALRRGD CTLALAGGVS VMATPLTFVE FSRQRGLSPD
     GRCRSYSADA DGTGFAEGVG VLLVEKLSDA LANGHHVLAV VRGSAVNQDG ASNGLTAPNG
     PSQQRVIEAA LVDAGLSTNQ VDVVEGHGTG TTLGDPIEAQ ALLATYGQDR SDPLWLGSVK
     SNIGHTQAAA GVAGIIKVVE AIRHGVMPAT LHAEQPSDQV DWTAGNVKLL TSATPWPETG
     RPRRAAVSSF GFSGTNAHVI IEQAPDQEVP GTASAPVTSL LVTARDPRAL RDQARRLASV
     VSTVDPAELG YALATSRTRF EHRAAVVGTS AAELADGLAA LARDEKAAGV VQGRVAEGKP
     AMLFSGQGAQ RLGMGLGLCE AFPAFAAAFE EVCAALDPHL DRPLRSVLET EELHQTGYTQ
     PALFAIEVAL FRLLESWGVT PSALVGHSIG ELAAAHVAGV FSLADAARLV VARGRLMQAL
     PSGGAMLAVE ATEDEVRPLL GADVDIAAVN GPRSVVVSGA EDAVAAVEAH FADRRTKRLT
     VSHAFHSPLM EPMLAEFRAV AQSIAYRESA LPILSTVDSA GDFTDPEYWV RQVRATVRFS
     DAVRAVEAKT LLEIGPDAVL ATMAADSVAD DVVLIPLLRK DRDEPRALVE ALARLEVRGV
     TVDAEAFYGR TGRSLVELPT YAFQHERFWM DSVQAFTAAG PGDPLRYEAK WERLPSGTAR
     TLTGTWLVVG PESAEVAGAL AANGATTVTA GLDGVAESLA EVAGVVSLLG AADTLKLIKT
     VAPQGVPVWA VTRGAVGTSP ADPVTDPDQA LVWGLGRVAA LELPQVWGGL VDLPAVLDDR
     TAAALATVLA GIGEDQVAVR PDGVFARRLH RAPAGPARRQ SVTGTVLVTG GTGTLGIEVA
     KAYADDGADH VVLLSRRGTA PAEALAGIDA RVTVVACDVA DRAALEAVAA QHDDIHAVVH
     VAGLAQLTPI ADMTDAEFAD VVSAKVEGAR NLDAVFPDVA EFVLFSSVAG VWGSGAQGAY
     AAANAYLDAL AAQRRARGKA ATSLAWGPWA GSNLVDDDID AALRKRGLSP MAPDRAVAAM
     RTALAAADTA VVLADVDWTA FVPSFTALRP SRLFDAIPEA VTETDTGSTD DLARLLADVP
     EADHLDHVTT LVRTQVALTL GYAGPEAVEA TRAFKELGFD SVTAVEFRNR MIEVTGIRLS
     AAVAFDYPTP QALAEHLLAS GTHEVVSATG FSDEPIAIVG MSCRFPGGVA TPEQLWAMLR
     EGRDGIGPFP ADRGWDLDGL FHPDPEHPGT SYVREGGFLH DLPGFDAAFF GISPREAEAM
     DPQQRLVLEA AWTAFEDAGI DPTSLRGTPT GVFVGTNNND YIRLTGAVGA SAEGFMATGN
     AASILSGRLS YVLGLEGPAV TVDTACSSSL VALHLAVQGL RSGECSAAVA AGVTAMSTPG
     AFVEFSKMRG LAPDGRCKAF AAGADGTNWG EGVGVVVLMR LSDAVAAGHD VLAVIRGTAV
     NQDGASNGLT APNGPSQQRV IRAALANAGL EPSDVDVVEA HGTGTALGDP IEVDALFATY
     GQDRDRPLWL GSVKSNIGHT QAAAGVAGVI KTVLALKHGE LPKTLHVEEP TGHVDWSGGV
     RLLADAQPWP RGERPRRAGV SSFGFSGTNA HVIIEEPAEA PAPERPASPE PVALVLSARS
     QAALQQQAAD LLPLLDTEEP RDLAYSLSLR AHHARRAVVA GDLRAGLTAL AAGEPSPSVV
     TGTANPAGKV AFTFPGQGSQ WAGMAVELLD SSPVFAQRMA ECAEAIDRFT DWSLLDVVRA
     VEGAPSLDRV DVVQPVLFAV MVSLAALWRS HGVEPSAVIG HSQGEIAAAA VAGALSLEDA
     AKVVTLRSNA LLRLSGKGGM VSVPLPADQV RERIEHFAGR VTVATVNGPR STVVAGEPEA
     LEQLLAECAD NGVRAKKIDV DYASHSAYVE EIHDELLDVL QGLAPRTSDV PFYSTVDSCW
     LDTTLMDAEY WYRNLRQTVW FQPAVRALLD AGFTAFVESS PHPVLTIGVQ DIIDDAEATA
     SVVGSLRRDE GGLARFQLSV GEAHTHGVKV RWPHGDARKV RLPGYPFQHE RFWPEAGAVV
     ADAAGLGLSA ADHPLLGAAV AVADTDGLLF TGRLSVGTHP WLADHAVGGQ VLVPGTAFVE
     LAVRAGDEVG LGKVEELTLT APLVLPEKGA VQVQMWVGAP DETGQRPLKI HSRPNDDTPW
     TRHAVGLLGE ADQPTTFEPV WPPEAEELPV ADLYDTLATA GLHYGPSFRG VRRAWRRDDE
     ILAEVGLPEP AGKAAFGLHP ALLDAALHPL ALSTTSQGPL LPFAWTGVSL HAAGATTLRV
     RLRPTGQNAV ELTATDHTGT PVATVESLVL REAAAPTTQT THHDALFRLD WTPLTTSTDL
     SYPGGTLETG AGGHRWATLG TLDLPRKAGL VTDTYATLAD LKTALDNGAP VPDRVALPCF
     QTAQDPVQGA YQAVTTTLET LREWLADERL TESKLVVVTR NAISTHDPAE DLAHSPIWGL
     VRSAQTENPD RFVLLDIDDR DPHRALTTTE PQLAIRDGVA YVPRLARATT TPALVPDTDR
     WRLDVTEKGT LDNFALLPAG DPKPLGPGQV RIAMRAAGLN FRDVLIALDM YPGDGVMGGE
     GAGVVVETAP DVEGITPGDH VMGLFHDAFA PEVVTDARMV VRVPKGWSFA TAAATPIAFC
     TAYFALVDLA EVKPGEKVLI HAAAGGVGMA AVRLARHLGA EVFATASPGK WDALRGMDLD
     DDHIANSRTL DFEDKFHGID VVVDSLAKEF VDASLRLLRP GGRFIEMGKT DVRDPDKVAQ
     DHRGVAYQAF DLLAIDPDRV AAILRDVLAL FEDDKITPLP IKPYDLRRAP EAFRFMSKAK
     HVGKLVLTVP PRRDPDGTVL ITGGTGTLGG LLAKHLVTDH GVKHLLLTSR RGLQAEGAAD
     LAAELTALGA QVTIAAADAA DRGQLAEALA LVAPEHPLTS VIHTAGVLDD GVVTALTEDQ
     VRNVLRPKVD AVVNLHELTH DLAEFTVFSA AAGTLGGPGQ GNYAAANVFL DTLVAQRRAA
     GLPAQALAWG LWGEASGMTA HLDANDRARM ARGGLLELSV AQGMALYDAA QRIDEPLLVP
     MPVDPTALRE LSRVDMLPVL LRGLVRGPAR RTLEATQSAG AFKDELLRQS GPQRRHTALE
     LVKAQAATVL GHSSANAVEP NKPFTELGFD SLTAVEFRNR LKAATGLKLP ATMVFDYPTA
     AALTDFLLAE LAPAEVDPAE ALLGELDVLE RSLAGADVDE SVKARITERL QAVLSNWRGQ
     SDAGADAGGP DVDTVLKTAS ADELLRFIDD ELGAA
//

DBGET integrated database retrieval system