ID A0A496PM45_9MICC Unreviewed; 1115 AA.
AC A0A496PM45;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DWQ67_01890 {ECO:0000313|EMBL:RKW71618.1};
OS Galactobacter caseinivorans.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Galactobacter.
OX NCBI_TaxID=2676123 {ECO:0000313|EMBL:RKW71618.1, ECO:0000313|Proteomes:UP000273119};
RN [1] {ECO:0000313|EMBL:RKW71618.1, ECO:0000313|Proteomes:UP000273119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JZ R-183 {ECO:0000313|EMBL:RKW71618.1,
RC ECO:0000313|Proteomes:UP000273119};
RA Hahne J., Isele D., Lipski A.;
RT "Arthrobacter sp. nov., isolated from raw cow's milk with high bacterial
RT count.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKW71618.1}.
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DR EMBL; QQXL01000001; RKW71618.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A496PM45; -.
DR Proteomes; UP000273119; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000273119}.
FT DOMAIN 1..305
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 338..657
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 326..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 19..26
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1115 AA; 118063 MW; 58253C738431C751 CRC64;
MNLPQLISQP GHGPVLVVGG PGTGKSTVAL EVVIDRLRAG THQDAILALV PTRQQADRLR
DELALRSGAT FAEPVVRTYS AYAFDLIRLA REQGLIRADG RPPRLLAGAD QDAFIAELLR
GHREHGGGPA WPDSLGQAVG TRGFRQELRQ FLDRVSEWGL EADDVEGLGR RCGVPEWGAC
AQFLREYRRV GQLAHSEAFD PAELVGLALK VLRAFPDFAA VQTGGLELLV VDDLQEATGS
QHALVRFLAD PARGRRDAVL LASPDTVVQG FRGARPDLVR LLPGELGGDN GPAAVVELTQ
NFRLSAPLST AIRRVMLRIP SATGELGRRW EPRPEEGAAA GQAAGTAAGQ AAGPATGPAG
AGASAAEPPV DVRVVESVVH RDRLVSRHVL EAHLSRGVAY EDIAVIVRNG AQVRSVSRAL
GLDGISTEVP PVEIPLREEA AVLPLLALLE RALVPAAPRV RDPREALADA AAVQSLLTGP
YGRASSLDVR WLRQELLIHE RAARGPEAEG PAPSSTQLLA ALLDGGYTAS ELRALGTTAL
PGVRLLDMLA AARQHLEGEH TPSTAVWALW DTARAAEPWR EQALGEHGLR GDRAHRDLDA
VMALFQAAER YVDQHPGASV PDFLDHVRGQ ELPMDSLART GSTSGRVKVL TPAAAAGLEW
DTVIVTGLEE GLWPSTGLRG QLLRSDELAT VAELGPQALR DSTVAQKLRA VRDDELRQFV
TALSRARTQL HLIGISGDDA TPSSFLELVR SDHAEPLVIT AVPRPRTLTT LTALLRRTLE
AGADEAAADA AGVLALLSLA EPPVPGADPA RWWGLAPLSS ADPIVAPGAA VRVSPSKVES
VLNSPLNWFI QAAGGVAPVD FARSLGTLIH SIAEQYPEAS QEQLLVALHH RWDELEMPQN
WLGSTERERA ERMLGRLAGY YESASAAGRS LVGLEQGIGV DLEPRSPGEH PVRINGSIDR
VEADAEGRPY VVDLKTGKLI PTAVEAQQHP QLATYQAAIL AGALLAPQET LPDDVGVGDN
VGAGDRAGLT GLGDPTHPAG AALVAVGTET AKATVRAQAP IEAEENWAAD MVADAAELMS
RADFVAMHEQ GGAAVRCTLP GACPLCAEGR QVTEP
//
