ID A0A497XDL1_9PROT Unreviewed; 410 AA.
AC A0A497XDL1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Membrane fusion protein (Multidrug efflux system) {ECO:0000313|EMBL:RLJ65053.1};
GN ORFNames=DFR35_1709 {ECO:0000313|EMBL:RLJ65053.1};
OS Sulfurisoma sediminicola.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Sterolibacteriaceae; Sulfurisoma.
OX NCBI_TaxID=1381557 {ECO:0000313|EMBL:RLJ65053.1, ECO:0000313|Proteomes:UP000268908};
RN [1] {ECO:0000313|EMBL:RLJ65053.1, ECO:0000313|Proteomes:UP000268908}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26916 {ECO:0000313|EMBL:RLJ65053.1,
RC ECO:0000313|Proteomes:UP000268908};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLJ65053.1}.
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DR EMBL; RCCI01000005; RLJ65053.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A497XDL1; -.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000268908; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000268908};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 39..346
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 65..279
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 368..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 130..161
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 368..394
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 42491 MW; 9BB896A3AF909989 CRC64;
MKNTLPPTAA LIAMLLVAGC GDGGKKAPAA GAPGGMPPPE VDVITVTPGN ATITQDLPGR
LLAVRSAQVR ARVEGVLEKR LFAEGSDVAA GKPLFQIDPR TYQAGAAAAE ADLAAAKATF
ERYKPLLDIK AVSQQEYDGA LARYKQAEAQ LSKARLDLEN AVPRAPISGR AGRALVTEGA
LVGKGEATHL VTIEQLDPIR AEFTQTYSDL LRLQQAVKAG KQKKADAAKV ELVLEDGSIY
AAKGQVQFTD LAVDPNSGSV ILRAEFPNPN RELLPGTFVR IRFPQAQLDD AIRVPQRAVQ
GGPTGQLVMV VDAEGKAMAR PIKTSAMSGT DFIISDGLKG GEKVIVNGLQ KARPGTVVKA
VPWNPAAPIM PPPAAGAPAA PGAPAAPPAP APQAKPAEAA AAAKPAEEKK
//
