ID   A0A497XE90_9PROT        Unreviewed;       780 AA.
AC   A0A497XE90;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:RLJ65310.1};
GN   ORFNames=DFR35_1970 {ECO:0000313|EMBL:RLJ65310.1};
OS   Sulfurisoma sediminicola.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Sterolibacteriaceae; Sulfurisoma.
OX   NCBI_TaxID=1381557 {ECO:0000313|EMBL:RLJ65310.1, ECO:0000313|Proteomes:UP000268908};
RN   [1] {ECO:0000313|EMBL:RLJ65310.1, ECO:0000313|Proteomes:UP000268908}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 26916 {ECO:0000313|EMBL:RLJ65310.1,
RC   ECO:0000313|Proteomes:UP000268908};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLJ65310.1}.
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DR   EMBL; RCCI01000005; RLJ65310.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A497XE90; -.
DR   OrthoDB; 9761531at2; -.
DR   Proteomes; UP000268908; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268908};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        355..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        445..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        476..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          532..701
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   780 AA;  84437 MW;  55A0758ED087795B CRC64;
     MRTVVLAFAA GIGWLQWQPA LPSAFQLAVS AMIGIPLLAT LRLPRWRVLG AVAAFLLGIA
     WAGWLAGERL AESLPTSLEG RDIEVVGVVA GLPQRYDNGW RFDFDIEQAP AALPARVSLA
     WYRGLRREED DDNHVAPEIR AGERWRLKVR LKRPHGNLNP HGFDYEAWLF ERGIRATGYV
     RPGDGNVGLD SLVARPAYVV ERLRQLARER FARVLGDPQQ GGAIYGGVLT ALAIGDQRAI
     DAELWRVFGR TGTTHLMSIS GLHVTMVAGL GWWLASWLWR RSARLPLWLP AQKAAAAAGF
     LVALLYCLLS GFAVPAQRTL YMLGVVAVAL WSGRSVSGSR VLASALLLVL LLDPWAVLAA
     GFWLSFGAVG LLFYIGGGRL AGGHWLAIWL RAQWAITLGM IPALLALFQQ FSLVSPLANA
     VAIPVVSLVV APLALVGALP LTDPLLWLSH AVLAALMGLL QWLAVSDWAV WQQHAPPAWA
     VLAGTAGVAW LLLPRGFPAR WLGLVALLPL FLVPPERPPA GEASVVVLDV GQGLAVHVQT
     AGHDLLFDSG PAFSPDANSG NRIIVPYLRA NGVRRLDAMV VSHADRDHSG GARSVAEELP
     VGRLLTSLPD GHDLLALPLV QQPCRDGAGW EWDGVRFDLI HPAAGDAERY RKSNDLSCVL
     RVTAAGRSAL LTSDIEARAE AALLARHGER LAAEVLLVPH HGSRTSSSPD FVAAVGARET
     IFPVGYRNRF GHPKAEVVAR YEGTRQWRSD RDGALSVRLG AAGVTIMAER AERRRYWHGS
//