ID A0A498CPS6_9FIRM Unreviewed; 787 AA.
AC A0A498CPS6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=D4A47_08310 {ECO:0000313|EMBL:RLL10636.1};
OS Anaerotruncus massiliensis (ex Liu et al. 2021).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Anaerotruncus.
OX NCBI_TaxID=2321404 {ECO:0000313|EMBL:RLL10636.1, ECO:0000313|Proteomes:UP000276301};
RN [1] {ECO:0000313|EMBL:RLL10636.1, ECO:0000313|Proteomes:UP000276301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=22A2-44 {ECO:0000313|EMBL:RLL10636.1,
RC ECO:0000313|Proteomes:UP000276301};
RA Wang Y.-J.;
RT "Anaerotruncus faecis sp. nov., isolated from human feces.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLL10636.1}.
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DR EMBL; RCHT01000013; RLL10636.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498CPS6; -.
DR Proteomes; UP000276301; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000276301}.
FT DOMAIN 22..343
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 344..616
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 787 AA; 88435 MW; 95219AC49708D2E5 CRC64;
MDLSLKDRYT AARRRIIDDF FSRMNPMQKQ AVYTLNGPVL ILAGAGSGKT TVIINRIANM
VLFGDAYHST WMPEQVTAED VAFLEEYADG ESWDSDRAFT LIRSHTVMPW NILAITFTNK
AAGELRERLS AMLGPTADDV GASTFHSACV RILRREIERL GYGRSFAIYD TDDSLRVIKG
ALKELNIDDK RFAPKGVLSA IGRAKDELLT PGGYEAGVGD DYYKQVVAKV YEIYQKQLQD
ANAVDFDDII MLTVRLFKEF PEALDYYRNR FRYIMVDEYQ DTNRAQFELV RLLASESGNL
CVVGDDDQSI YKFRGATIEN ILQFEDNFPG AKVFRLEQNY RSTETILDAA NAVISNNTER
KGKTLWTRNG EGVKVRVHRA ADENGEAQFI CDTIQANVQA GAKYSDHVVL YRMNAQSQML
ERGMVKAGIP YRIIGGLRFY ERKEIKDIVS YLSVLSNRSD SLRLRRIINE PKRKIGDSTV
NAVVEIAAGT GATMFDVLEH ADEYASLGRK TADLMAFAAM MRGLMEAADT LPLGELLDEL
LDRTGYLAML QAEGFEGQTR IENIEELKST MNRYEEENAE HSLSGFLEEI SLYTDIDKYD
PNDDAVVLMT MHSAKGLEFD NVFIAGAEEG IFPGVQAMYD PAQVEEERRL AYVSITRAKK
QLYISDAAQR MLFGQTMRNR PSRFLAEIPP ELCETEDETL LRRQQAAAMP AKKPRYSESD
RMLGVGRQPV PDEGFDLRPG DGVTHKVFGG GMVISVTPMG NDHLVEVAFD GVGTKKVMAK
FARLKKV
//
