ID A0A498DHS4_9PROT Unreviewed; 326 AA.
AC A0A498DHS4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=lipopolysaccharide heptosyltransferase II {ECO:0000256|ARBA:ARBA00044042};
DE EC=2.4.99.24 {ECO:0000256|ARBA:ARBA00044042};
GN Name=waaF {ECO:0000313|EMBL:RLL50913.1};
GN ORFNames=D8Y20_10495 {ECO:0000313|EMBL:RLL50913.1};
OS Mariprofundus sp. EBB-1.
OC Bacteria; Pseudomonadota; Zetaproteobacteria; Mariprofundales;
OC Mariprofundaceae; Mariprofundus.
OX NCBI_TaxID=2650971 {ECO:0000313|EMBL:RLL50913.1, ECO:0000313|Proteomes:UP000270267};
RN [1] {ECO:0000313|Proteomes:UP000270267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EBB-1 {ECO:0000313|Proteomes:UP000270267};
RA Lopez A., Barco R., Canela R., Emerson D., Tully B., Abuyen K.,
RA Broomell S., Albino D., Beraki S., Dingmon T., Estrada S., Fernandez M.,
RA Amend J.;
RT "Genome Sequence of Zetaproteobacterium sp. EBB-1: a novel, marine, iron-
RT oxidizing chemolithoautotroph isolated from an iron-sulfide mineral.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-
CC [alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-
CC (1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid
CC A + H(+); Xref=Rhea:RHEA:74071, ChEBI:CHEBI:15378, ChEBI:CHEBI:61506,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:193069, ChEBI:CHEBI:456216;
CC EC=2.4.99.24; Evidence={ECO:0000256|ARBA:ARBA00043830};
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLL50913.1}.
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DR EMBL; RCFQ01000027; RLL50913.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498DHS4; -.
DR Proteomes; UP000270267; Unassembled WGS sequence.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011910; RfaF.
DR NCBIfam; TIGR02195; heptsyl_trn_II; 1.
DR PANTHER; PTHR30160:SF7; ADP-HEPTOSE--LPS HEPTOSYLTRANSFERASE 2; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000270267};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RLL50913.1}.
SQ SEQUENCE 326 AA; 35254 MW; A5CF5C1D82FC12FA CRC64;
MTKDQHLVLM PPNWIGDVIM AQPALKSIAT YYAQHGTAQI SVCGRAWLKE LLPYLGLNHA
QYQSSIPAAD TAFLFPNSFR SAWQCRQAGI KQIIGYRGQW RSLLLSRALP HRIDTLHQHH
RLFHLDIAAQ MNIPTEDTAV TLSSPAGDKL AGQKLMQQHG LDPERVICIA PGAQFGAAKC
YPPDGFHAVV KQLADTGSQP LTLGMPEDHA TSQQIIADIT SPHWNAAGST NMTEALQLIS
ASKLMLCNDS GLMHVAAGLG IPTVTPFGAT DPARTAPSGP RVNVLYQPAD CSPCLQRECS
VSGHPCMANI TPTMLLDACR SMLADH
//
