ID A0A498DP27_9BACI Unreviewed; 626 AA.
AC A0A498DP27;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:RLL45482.1};
DE EC=5.4.99.17 {ECO:0000313|EMBL:RLL45482.1};
GN Name=shc {ECO:0000313|EMBL:RLL45482.1};
GN ORFNames=D8M04_11585 {ECO:0000313|EMBL:RLL45482.1};
OS Oceanobacillus piezotolerans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=2448030 {ECO:0000313|EMBL:RLL45482.1, ECO:0000313|Proteomes:UP000270219};
RN [1] {ECO:0000313|EMBL:RLL45482.1, ECO:0000313|Proteomes:UP000270219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YLB-02 {ECO:0000313|EMBL:RLL45482.1,
RC ECO:0000313|Proteomes:UP000270219};
RA Yu L.;
RT "Oceanobacillus sp. YLB-02 draft genome.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLL45482.1}.
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DR EMBL; RCHR01000003; RLL45482.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498DP27; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000270219; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051007; F:squalene-hopene cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:RLL45482.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000270219};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..292
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 306..622
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 626 AA; 71699 MW; CBEE6458F8979594 CRC64;
MNSRIKDEIN RIVEVLRNDQ SPDGSWDYPF ESGLSTDAYM IILLRTLEIN DEKLIQDLVE
RILSRQEKNG AWKLFDDEKN GNITATVEAY YALLYSGYRH EGDKEMAAAR RRILAWGGIE
KSHMFAKIML ALTGQYKWPT FFPIPVEFIL LPLSFPINFF DFPVYGRAHI APMLILADQK
FAMKTKRSPD LSNLFLSREN DEFFLNPSGE SRSFHTFIQQ GIKNNIGLPA SIHTMAIQQT
KKYIFDRIEP DGTFYNFFSS TFLMIFALLA LKFPKNDRII TKAIDGLKGM ATQIDGHTHM
QFTTANVWNT SLINDSLQRA GIPWNDPMIQ QANHYLLSRQ HSRYGDWMIH NPAPNPGGWG
FSDLNTMNPD IDDTTASLRS ITHLVRNETV YRQAWDRGIN WIFSMQNQDG GWGAFEKNVD
KKIVKLIPIK RIQYILTDPS TADLTGRTLE FYGNYTNLSN KHIAIKNGVN WLKSNQEKNG
SWYGRWGICY IYGTWAAITG MISTGVDTEH AYIKKSLKWL RDIQNPDGGW GESCYSDINQ
TYTPLGVSTL TQTAWALDTL IAASDKVTPE IQAGVTFLLD NADIKDWTFS YPKGQGLPGA
LYFHYHSYRY IFPLLALSHY KNKFLV
//
