ID   A0A498DUK8_9ACTN        Unreviewed;      1087 AA.
AC   A0A498DUK8;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Adenylate/guanylate cyclase domain-containing protein {ECO:0000313|EMBL:RLL69328.1};
GN   ORFNames=D7M15_23635 {ECO:0000313|EMBL:RLL69328.1};
OS   Streptomyces sp. Z26.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2500177 {ECO:0000313|EMBL:RLL69328.1, ECO:0000313|Proteomes:UP000288048};
RN   [1] {ECO:0000313|EMBL:RLL69328.1, ECO:0000313|Proteomes:UP000288048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Z26 {ECO:0000313|EMBL:RLL69328.1,
RC   ECO:0000313|Proteomes:UP000288048};
RA   Buchmann A., Cano-Prieto C., Baz M., Hassani L., Barakate M., Nafis A.,
RA   Niedermeyer T.H.J., Gross H.;
RT   "Draft Genome Sequence of the Novonestmycin-Producing Strain Streptomyces
RT   sp. Z26, isolated from potato rhizosphere in Morocco.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLL69328.1}.
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DR   EMBL; RCHV01000002; RLL69328.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498DUK8; -.
DR   OrthoDB; 5476461at2; -.
DR   Proteomes; UP000288048; Unassembled WGS sequence.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288048}.
FT   DOMAIN          46..176
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          929..951
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1039..1087
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1087 AA;  112620 MW;  8A5AB130D0F8C811 CRC64;
     MTAPAPVRCP RCPEPPPDGA AFCPRCGAAC EAAADTAAVE ERRVVTVVFC DLVGSTALSG
     RLDPETLRTV TLRYFALMRA RIEEHGGTVE KFIGDAVMAV FGVPARHEDD ARRALAAAHA
     MVTGLDVLNA DLEREHGVRL AVRIGVNTGE VVAGIDPAAR QALVSGEVVN IAARLEQHAG
     AGEVLIGPDT ADAAGPSAVT EPAGSLALKG VAAALPARRL LGLHEDDPER MRRFDTPFVG
     RSQELAELRL LLGKLAADPA SYLVTVYGEA GLGKTRLLRE WLRDCPAYGA GRCRPYGETG
     TLAPLAEAVR HILDTVGEDA GLAGLPGAER AEADQALRLL RSGLLADGTP SPSTDDTVMA
     LACLLDGLSR ERPVVLVLDD CHWAAEPLLD MAARLLDELD RAPVALVCAA RPELLETRPG
     WGSGRMRAAS LMLTPLTREE SAELAGGLVE VAAHRHGVLE GALDRAEGNP LYLEHLTALA
     AEGDDDLPVT VHALLGARID ALPPEERALL QLAAVLGREF RRTDLTELAA GPGDGAVPGV
     PGESAATLRG LVRRRLIETG GRGPVAGAEL RFGSGLVQET AYRGMAKKVR ARHHEDAARV
     LGRHAGADAA VGNHLARAHR LRAELGTHDG DTDALRARAA ALLARAGTAA LARSDLPWAD
     DLLGQALDLA APGEPAAAEA ARGLGETKVA RGEPARGREL LAGALADAER AGDRYGSAHA
     RLALTALDPR HGSAAEVAAT ALPLFEAAGD DRGVARACVR LAQDRQRRGR HAEAEALLRR
     ALEHADRADA EPERALALGA AGISLWRGPT PVADAVARCA ELLAAHGAGR PTVRATLTCP
     LAVLLALRGR YAEARERLAE AERLADGLGY AEGALFIPLF AAEVEALAGT PERRLGLLAE
     AARAGRELGA EGALPGIARD RARTLLDGGD PAEALALPDP ADADLPPAES ADAHGLRARA
     LALAGRADEA RARAVRATAV AGDTDSPVVR GTAALDLART LRTLGLPGEA AREARTALRH
     FTAKGHRLGA DRATAFAADS AAAAGTPENG TARDGTAVDG PAGRAAGSSV AEGRETGPTD
     ARKGGTP
//