ID A0A498E1S9_9ACTN Unreviewed; 720 AA.
AC A0A498E1S9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=MMPL family transporter {ECO:0000313|EMBL:RLL70752.1};
GN ORFNames=D7M15_24325 {ECO:0000313|EMBL:RLL70752.1};
OS Streptomyces sp. Z26.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2500177 {ECO:0000313|EMBL:RLL70752.1, ECO:0000313|Proteomes:UP000288048};
RN [1] {ECO:0000313|EMBL:RLL70752.1, ECO:0000313|Proteomes:UP000288048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z26 {ECO:0000313|EMBL:RLL70752.1,
RC ECO:0000313|Proteomes:UP000288048};
RA Buchmann A., Cano-Prieto C., Baz M., Hassani L., Barakate M., Nafis A.,
RA Niedermeyer T.H.J., Gross H.;
RT "Draft Genome Sequence of the Novonestmycin-Producing Strain Streptomyces
RT sp. Z26, isolated from potato rhizosphere in Morocco.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLL70752.1}.
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DR EMBL; RCHV01000002; RLL70752.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498E1S9; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000288048; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000288048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 162..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..306
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 75397 MW; 3209B70C63BF65D6 CRC64;
MAAGAASGTR ELSGSEQLPG TETGDTMRVV EDAGLEEPAG ESVLVQSGPD GPKATSAEFR
RAVEQVVAAV RETGETTAPT SPYETGTVSA DGRSALVHFD MRGDPETAGD RVQPVLDAVR
DVREDHEGTL RIEEIGDASM NKTFDDAFGA DFRQAEFSAV PVAFGILLIA FGALVAALLP
VLLALTAIMA TMGLMGVASR FQPMTETANS VMLLVGLAVG VDYCLFYLRR EREERARGRD
ARTALDIAAA TSGRAVLISG VTVIVAMSGM LFTGLAEFEG MGLASLMVVA VAMVGSVTVL
PALLSLLGER VEKGRVPFLA RLKRGPAGGS GESRVWRAVL DRVLRRPRTA VVLAAGVLAA
VAVPAVGMNT ANLTLDQEFG DSLPIVGTYE RVDAAFPGGS DPARVVVRAD DIDAPPVRAA
LADFRARAVS EGASRGPVEV VTHERENVAT IEVPLVGGSD QAKAERSLAV LRDEVRPATL
GRVDGVEAPI GGSVAASKDF NDRLVGAVAP VFAFVVLFAF ALMLLSFRSL TIAVTSIVLN
LLSVGAAYGI LTVVFQHGWG AGLVGAEGIG AIISWLPLFL FVILFGLSMD YHVFVVSRVR
EARTAGRDTA DAVRHGVITT AGVVTSAAVI MVAVFAIFGT LSMQSMKQMG VGLAAAVLID
ATVIRGVLLP AVMVLLGERN WYLPRWLDWL PDLTHDEAVP AARDTPPVAD RGADGPAVRV
//
