ID A0A498E386_9ACTN Unreviewed; 3527 AA.
AC A0A498E386;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=SDR family NAD(P)-dependent oxidoreductase {ECO:0000313|EMBL:RLL68247.1};
GN ORFNames=D7M15_16945 {ECO:0000313|EMBL:RLL68247.1};
OS Streptomyces sp. Z26.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2500177 {ECO:0000313|EMBL:RLL68247.1, ECO:0000313|Proteomes:UP000288048};
RN [1] {ECO:0000313|EMBL:RLL68247.1, ECO:0000313|Proteomes:UP000288048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z26 {ECO:0000313|EMBL:RLL68247.1,
RC ECO:0000313|Proteomes:UP000288048};
RA Buchmann A., Cano-Prieto C., Baz M., Hassani L., Barakate M., Nafis A.,
RA Niedermeyer T.H.J., Gross H.;
RT "Draft Genome Sequence of the Novonestmycin-Producing Strain Streptomyces
RT sp. Z26, isolated from potato rhizosphere in Morocco.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLL68247.1}.
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DR EMBL; RCHV01000002; RLL68247.1; -; Genomic_DNA.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000288048; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000288048};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..89
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 109..535
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1704..1779
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1798..2224
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3411..3486
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1113..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3527 AA; 368364 MW; FE941D5518AD5571 CRC64;
MHMTEQSRAA ILELVLSEAA DVLRAADPDG FDAAQLAADS PFLATGLDSL GLVRLHQRLV
AELGVDLPVT IAFDHPTPIA LARHLAELSG DGEPEESAVA DAAVPVASDE PIAVVGIGCR
FPGGVNSPED LWQVVADGRH VLTDFPSDRG WDLEALYDPE ASAPGTSYVR KGGFLDDAAD
FDAGFFQISP KEALAMDPQQ RLLLETCWEA LEHAGIDPGR LHGTQSGVFI GVEPHEYGPR
THEAPDGVDG YVLGGSLPSV VSGRVAYTLG LEGPTLTVDT ACSGSLTALH VAVRTLQRGE
CGVALAGGVT VISTPGTFTT FSRQRGLAPD GRIKAFGAGA DGTCFAEGAG VFVLTRLSDA
VRDGHPVLAV IRGSAINQDG ASVSLTSPNG LAQQRVIRAA LGDAGLTAAD VDVVEAHGTG
TELGDPIEGQ ALVAAYGRER TADKPLWLGS LKSNIGHTGA AAGAAGMIKM IMAMRNRTLP
RTLHADEPTP HVDWSAGTVR LLTEHLPWET DGAPRRAGIS SFGASGTNAH VVIEEPPATA
PEPATEEAPE TGRPVPVVLS ALGQDALRGQ AARLLAVADR ESPLDLAYST ATTRAALRDR
ATVVAADRDE LVRGLTALAE GTTAPGLVTG TAVAAGRTAF LFTGQGSQRL GMGRELVRAF
PAFREALQDV ADHLDLHLDE PLGDVLFAEP GTPGAELLNE TRYAQAALFA VEVSLFRLLE
SWGVTPGFLI GHSIGEIAAA HVAGVMSLAD AAMLVGARGR LMQELPEGGA MVAVQAEEAE
VTPYLTEHVG IAAVNGPTSL VLSGETEAVR AVAARFAEQG RKTRQLRVSH AFHSSLMDPM
LEEFRGVAEI VAYAPPRIPV VSNVTGEPVT AFDADYWVRH VREPVRFADG MRHLAARGVT
TYLELGPDAV LSAMGRECLG DDGADAVLVS LLRDKHGDER QTVTALGQAH ANGTTVDWDA
FHAGRGARRV GLPTYAFQRR RYWLDVVSGP ASGVGHPMLD SAVSLAGADG LVLTGRLSTR
AQPWLADHVI ADTVLVPGTG LVELAVRAGD EAGYAVLDEL TLEAPLVLTG DDAVEVQVSV
NAPDASGRRP VEIWSRAARG GDTWSRHASG VLAERSDGPA PDPSALAQWP PADAEPLDVD
GLYERQAAQG YGYGPVFQCV RAAWRRGTEV FAEVALPDGE DGSPFGLHPA LLDSSMHASE
NADDDGEVRL PFAWVGVELH ASGASAARVR LTPNGPDDLS ALLADSTGAP VASIRSLVQR
PVAKGGLGAS GGRRDPLLRV DWTEVQAPAE PDDAAERFTL AYVPETFSGA PAEAARAATE
HVLELVRGAL RDDARLALVT RGARGDLALA PATALVRAAQ AEHPGRFVLV DTDREVSEHE
IRTALATGEP QLALDGGTVR VPRLARVEVP EESGTSVWGP DGTVLITGGT GGLGGLVARH
LVREHGVRHL LLTGRRGADT PGVTELAAEL RESGAEVTVA ACDVADRDAL AALLATVPEE
HPLTGVVHSA GVVADGLVDS LTPEQVGTVF HGKADGAWHL HELTRELPLT AFVLFSSAAG
TLEAAGQGNY AAANAFLDAL AGHRAARGLP ATSLAWNLWA GEAGMGARLD EVTLRRAERS
GLPALTADEN LALFDQALTT DAPALVPLRF DAAALRNRAD GVPHLLRGLV RAPARRQAAA
VAAGAAGGSL AERLAGKPDN ERDRMVLDLV RTQIAAVLGH DSGNSVDARR QFTELGFDSL
AAVELRNALT AATGLRLTST LIFDHPTPRD LADHVLETVR GAAPATAAVR APSRATADEP
IAIVGMACRF PGGVTSPEQL WQLVADGTDA IGPFPEDRGW NVDEIFDPEP GKHGRTYTRD
GGFLYDAAEF DPTFFGISPL EAQAMDPQQR LLLEVGWEAL ERAGIDPRSL KGSPTGVFAG
IMYHDWAPRS SQVSEDLAGF TAAGSLGSAA SGRVAYTLGL QGPAITVDTA CSSSLVAMHQ
AAQALRQGDC TLALAGGATV MATPETFVGM SLQQGLSTDG RCKAYGEGAD GTGWSEGAGF
VLLEKLSDAR RNGHPVLAVV RGSAVNQDGA SNGMAAPNGP AQTRVIQQAL GVAGLRPADV
DVVDGHGTGT TLGDPIEAQA LMAAYGQDRE DRDPLWLGSL KSNLGHAQAA AGVGSVIKMV
MAIRNGVMPR TLHADTPSPH IDWTEGAVEL LQEARAWNPE GRPRRAGVSS FGVSGTNAHL
ILEQVPAEPR ADVPRGDRLP VVPLTVSGTT PAAVRDQAAR LAEHLRDHAD VDELDAAVSL
VRGRAALEHR AVVFDADRDG LLSGLDALAA GGSAASLVQG VQRGDARAVF VFPGQGSQWQ
GMGVELLEHS PAFATRLGEC GKALEPYVEW DLLDVLRGAP GAPALDAVDV VQPVLWAMMV
SLAEAWRAVG VEPAAVVGHS QGEIAAACVA GALSLEDGAR VVALRSQVIR QDLAGRGGMM
SVALSEDRVA EYAAQWGDRL QLAVVNGPSS VVVCGDPDVL DELKTKLDDD GVQARRIPVD
YASHSVFVEE IRERLFAELG ELEPRVPSIP FYSTVTAGRL DTAGLDAEYW YTNLRQTVRF
EETTRALLAD GFEIFVETSP HPGLLVGLGE TAESVGANPA LVATLRRDEG GPRQFVNSLS
EAYAQGATVD WVTYLAGTGA RHVDLPTYAF QRRRYWLDLA ESGGDASQVG QVATGHPLLG
AAVPVAGAGG VLLTGRLSVS AQPWLADHVV DGAVLFPGAG FVELAVRAGD EIGRGGVDEL
TLEVPLVLPE RGGVAIQVIV DADLCGVSIH SRHEGAPVDV GWTRHAHGTL VETRPEPAAD
TSVWPPPGTE PVDLENFYDA SPEGGLAYGP VFQGLRAAWR NEGGEVFADV ALPESVTGEA
GRYGLHPAVL DATLHATALL PGGDDRVTLP FLWTRVDLYA AGASALRLRM TPLGGDEVAL
RLTDTAGRPV ADVESLVLRP VTDGLIAGAG TAHESLFDLV WSAAPLPDEW PVTTPAVLRS
AAGSTAEEVH AATAAALDFL QRGLGDDGDL DTTLAVVTRG AVSVAGEDVV DLAGAAVWGL
VRSAQTENPN RIVLVDLDPS VVDGDEFDRV LAAALSAGEE QVAVRSGTYH RPRLVRWTGD
RSGTPASVFG ERPGTVLITG GTGTLGSLFA RHLVTAYGVT DLLLTSRRGS AATGAAELAE
ELTGLGANVE IAACDAADRN ALAAVLDGRT LAGVVHTAGV LDDGIIPSLT PEKLTSVMRP
KVDAALNLHE LTADQDLSAF VLFSSAAGVT GGAGQGNYAA ANTFLDGLAA HRRAQGLPAQ
SLAWGLWAEA SGMTGALGAG DVSRMERDGV RGMSNEEGLA LLDTASAADR TLLVPARIDL
AGQRRAEVPY LLRDLVRAPA RRVVEAGTAS AEAAESLRDR LSGLAPARRE KAMLDVVCAQ
AAATLGYDGA DEVDPERSFR DMGFDSLAAV RFRNALGESV GERLPATLVF DHPTPLSLTR
HLLEELALDG PTDEPEANTD VADDRTEEIQ GMSLAELLRA ASQRSGE
//
