ID A0A498H7F7_MALDO Unreviewed; 778 AA.
AC A0A498H7F7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=DVH24_027406 {ECO:0000313|EMBL:RXH67286.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH67286.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXH67286.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXH67286.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXH67286.1}.
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DR EMBL; RDQH01000343; RXH67286.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498H7F7; -.
DR STRING; 3750.A0A498H7F7; -.
DR Proteomes; UP000290289; Chromosome 17.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0042300; F:beta-amyrin synthase activity; IEA:UniProt.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF58; BETA-AMYRIN SYNTHASE-RELATED; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 100..402
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 417..770
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 778 AA; 89527 MW; F06A8424834CB8DF CRC64;
MWKLKVADGG NDPYIHSTNN FVGRQIFEFD PEAGTTEERA EVEEARLNFY NNRYQVKPNS
DLLWRMQFLR EKNFKQTIPP VKVEDGEKIT YEKATFALRR SVYFFSALQA GDGHWPAENA
GPLFFLPPLV MCTYITGHLN TVFPAEHRKE ILRYIYYHQN QDGGWGLHIE GHSTMFCTAL
NYICLRILGE GPDGAQDNAC AKARKWILDH GSVTHIPSWG KTWLSILGVF EWSGSNPMPP
EFWILPSFLP VHPAKMWCYC RMVYMPMSYL YGKRFVGPIT PLILQLREEL YAQPYDEINW
KGVRHHCAKV DIYYPHPWIQ DFLWDSLYVC TEPLLTRWPF NKLIRKRALE VTMEHVHYED
ENSRYITIGA VEKVLCMLAC WVEDPNGDYF KKHLARIPDY LWVAEDGMKM QSFGSQQWDT
GFAIQALLAA NLTDEIAPTL ARGHDFVKKS QVKDNPSGDF KSMYRHISKG SWTFSDQDHG
WQLSDCTAEG LKCCLLLSMM PPEIVGEKME PERLYDAVNV IISLQSKNGG LAAWEPAGAP
EWWEDIVLFS PQMFNPTEFF EDIVVEHEYV ECTSSAIQAL VLFKKLYPGH RKEEIDQFIT
AAVLYLENVQ MADVKKKNLV MKRLHRYGEW GVCFTYGTWF ALGGLTAAGK TFNNCAAMRK
GISFLLAIQK ENGGWGESYL SCPKKEYVPL EGNRSNLVHT AWAMMGLIHA GQAERDPTPL
HRAAKLIINS QMENGDFPQQ EITGSFKKNC MLHFPAYRNI FPLWALAEYC RRVPFVDV
//
