ID A0A498H824_MALDO Unreviewed; 833 AA.
AC A0A498H824;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=DVH24_027685 {ECO:0000313|EMBL:RXH67538.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH67538.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXH67538.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXH67538.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXH67538.1}.
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DR EMBL; RDQH01000343; RXH67538.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498H824; -.
DR STRING; 3750.A0A498H824; -.
DR Proteomes; UP000290289; Chromosome 17.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0042300; F:beta-amyrin synthase activity; IEA:UniProt.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF58; BETA-AMYRIN SYNTHASE-RELATED; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 99..357
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 489..713
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 833 AA; 95300 MW; 2A10F62967744C06 CRC64;
MWKLKVADGG NDPYIYSTNN FVGRQIFKFD PEAGTTEERA EVEEARLHFY NTRYQVKPNS
DLLWRMQFLR EKNFKQTIPP VKVEDGEEIT YEKATAALRR SVHFFSALQA SDGHWPAENA
GPLFFLPPLV MCTYITGHLN TVFPTEHRKE ILRYIYYHQN QDGGWGLHIE GHSTMFCTAL
NYICMRILGE GPDGGQDKAC ARARKWILDH GSVTHIPSWG KTWLSILGVF EWSGSNPMPP
EFWILPSFLP MHPAKMFCYS RMVYMPMSYL YGKRFVGPIT PLILQLREEL YAQPYGEINW
KGVRRHCAKV DIYYPHPWIQ DFLWDSLYVC TEPLLTRWPF NKLIRKRALE VTMEHVHYED
ENSRYITIGC VEKVLCMLAC WVEDPNGDYF KKHLARIPDY LWVAEDGMKM QSFGSQQWDT
GFAIQALLAS NLTDEIAPTL ARGHDFVKKS QVKDNPSGDF KSMYRHISKG SWTFSDQDHG
WQVSDCTAEG LKSKNGGLAA WEPAGAAEWL EMFNPSEFFA DIVVEHEYVE CTSSAIQALV
LFKKLCPGHR KEDIDQFITA AALYLENVQM ADGSWYGNWG VCFTYGTWFA LGGLTAAGKT
FNNCAAMRKA ISFLLAIQKE NGGWGESYLS CPKKEYVPLE GNRSNLVHTA WAMMGLIHAG
QAERDPTPLH RAAKLIINSQ MENGDFPQQE ITGAFMKNCM LHYANYRNIY PLSESNMAGS
TSSKLSTLFF NGRNYEFWRI RMKTILKSHG LWDLIEKGFE VPESNKELAE RATDAKKEKE
YSSTLAQEQM KDAKALGLIQ GELSLIKFHY ETMEESGELL IAVFIGRLLS GFN
//
