ID   A0A498HB29_MALDO        Unreviewed;       819 AA.
AC   A0A498HB29;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=DVH24_030989 {ECO:0000313|EMBL:RXH68656.1};
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH68656.1, ECO:0000313|Proteomes:UP000290289};
RN   [1] {ECO:0000313|EMBL:RXH68656.1, ECO:0000313|Proteomes:UP000290289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC   TISSUE=Young leaf {ECO:0000313|EMBL:RXH68656.1};
RA   Hu J.;
RT   "A high-quality apple genome assembly.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXH68656.1}.
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DR   EMBL; RDQH01000343; RXH68656.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498HB29; -.
DR   STRING; 3750.A0A498HB29; -.
DR   Proteomes; UP000290289; Chromosome 17.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0042300; F:beta-amyrin synthase activity; IEA:UniProt.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF58; BETA-AMYRIN SYNTHASE-RELATED; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..819
FT                   /note="Terpene cyclase/mutase family member"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019834372"
FT   DOMAIN          158..459
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          476..812
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   819 AA;  93574 MW;  7BBCBD2D17D5AB66 CRC64;
     MGASHFCEAI ASRFFGTVFV LLEVLPSVRR HRLPPQESSS QDESEIERIG EKERGGCARV
     EFGEDEDGGN DPYIYSTNNF VGRQIFEFDP EAGTTEERAE VEEARLHFYN NRYQVKPNSD
     LLWRMQFLRE KNFKQTISPV KVEDGEEITY EKATATLRRS VHFFSALQAS DGHWPAENAG
     PLFCLPPLVM CTYITGHLIT VFPAEHRKEI LRYIYYHQNQ DGGWGLHIEG HSTMFCTALN
     YICMRILGEG PDGGQDNACA RARKWILDHG SVTHIPSWGK TWLSILGVFE WSGSNPMPPE
     FWILPSFLPM HPGKMWCYCR SVYMPMSYLY GKRFVGPITP LILQLREELY AQPYDEINWK
     GVRHHCAKVD IYNPHPWIQD FLWDSLYVCT EPLLTRWPFN KLIRKRALEV TMEHVHYEDE
     NSRYITHGCV EKVLCMLACW VEDPNGDYFK KHLARITDYL WVAEDGMKMQ SFGSQQWDTG
     LAIQALLASN LTDEIAPTLA RGHDFVKKSQ VKDNPSGDFK SMYRHISKGS WTFSDQDHGW
     QVSDCTAEGL KCCLLLSMMP PEIVGEKMEP EQLYDAVNVL ISLQSKNGGL AAWEPAGAAE
     WLEMLNPTEF LADIVVEHEY VECTSSAIQA LVLFKKLYPG HRKEEIDQFI TAAALYLENV
     QMADGSWYGN WGVCFTYGTW FALGGLTAAG KTFNNCAAMR KAISFLLAIQ KENGGWGESY
     LSCPKKEYVP LEGNRSNLVH TAWAMMGLIH AGQAERDPTP LHRAAKLIIN SQMENGDFPQ
     QEITGVFLKN CMLHYAAYRN IFPMWALAEY RRRVPFVDV
//