ID A0A498HKY9_MALDO Unreviewed; 664 AA.
AC A0A498HKY9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=DVH24_018735 {ECO:0000313|EMBL:RXH71380.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH71380.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXH71380.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXH71380.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXH71380.1}.
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DR EMBL; RDQH01000342; RXH71380.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498HKY9; -.
DR STRING; 3750.A0A498HKY9; -.
DR Proteomes; UP000290289; Chromosome 16.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0031559; F:oxidosqualene cyclase activity; IEA:UniProt.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF44; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 86..306
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 323..661
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 664 AA; 75126 MW; E1CB16C4668A3E61 CRC64;
MHIINTKFAK EASEKKQVVS DQVKVKSGDE EEEVISEEAV EITLRRALRY YSTLQADDGF
WPGDYGGPLF LLPGLVIGLY VTGALHTILP HDQNQQEICR YLYNHQNIDG GWGLHIEGPS
TMFCTALSYV TLRLLGEEID GGDGAMDKAR KWILDRGGVT FIPSWGKMWL SVLGVYEWNG
NNPLPPELWL LPYSLPIHPG RMWCHCRMVY LPMSYLYGKR FVGPIDGLIL SLRRELYTFS
YHLIDWDQAR NLCAKEDLYY PHPLLQDMLW GSLHKVGEPL LKGWPFSKLR QKALRTIMQH
IHYEDENTQY ICIGPVNKGY NGSQCWDVAL AVQAILATNL FTESVSMLKK AHDFIKNTQV
RTNSSRNPSN WYRHISKGGW PFSTPDNGWP VSDCTAEGLK AALLLSSIPS EIVGEAVQTD
HLYDAVNVIL SLQNSTGGFA SYELTRSYPW LEMINPAETF GDIIIDYQYV ECTSAAIQGL
KSFMKLYPGH RRKEILACIA KAVKFIESIQ QPDGSWYGSW GVCYTYGTWF GIKGLVAGGK
TYQTSHSIRK ACDFLLSKQL DSGGWGESYL SCQNKVYTNL EGNKPHIVNT GWAMLGLIDA
GQAERDPAAL HRASKLLINS QMENGDFPQQ QIMGVFNKNC MISYSAYRNI FPMWALGEYR
NRVF
//
