ID   A0A498I790_MALDO        Unreviewed;       425 AA.
AC   A0A498I790;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5 {ECO:0000256|ARBA:ARBA00016279};
GN   ORFNames=DVH24_039798 {ECO:0000313|EMBL:RXH77827.1};
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH77827.1, ECO:0000313|Proteomes:UP000290289};
RN   [1] {ECO:0000313|EMBL:RXH77827.1, ECO:0000313|Proteomes:UP000290289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC   TISSUE=Young leaf {ECO:0000313|EMBL:RXH77827.1};
RA   Hu J.;
RT   "A high-quality apple genome assembly.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000256|ARBA:ARBA00005339}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXH77827.1}.
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DR   EMBL; RDQH01000340; RXH77827.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498I790; -.
DR   STRING; 3750.A0A498I790; -.
DR   Proteomes; UP000290289; Chromosome 14.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd00757; ThiF_MoeB_HesA_family; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   PANTHER; PTHR10953:SF9; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          65..319
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
FT   REGION          392..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  46647 MW;  918794E2569B44A6 CRC64;
     MEVELKELLS DLESLKKSLA DPSHHAPIDK LQLRVERLTS LANSGPVRRS KVKDMSAEVV
     DSNPYSRLMA LQRMGIVENY ERIRDFSVAI VGVGGVGSVA AEMLTRCGIG RLLLYDYDKV
     ELANMNRLFF RPEQSGMTKT DAAVQTLSDI NPDVVLESYT LNITTVQGFD TFMASLKNKS
     FRPNKEGSGV DLVLSCVDNY EARMAVNQAC NELNQTWMES GVSEDAVSGH IQLLIPGETA
     CFACAPPLVV ASGVDERTLK REGVCAASLP TTMGVVAGLL VQNTLKYLLN FGNVSPYLGY
     NSLKDFFPTM EMKPNPQCSN FACLDRQKEY LLVKPAKDAA IKAKMEAEAS SVPESPLHLD
     NEWEISVVDD NEPESTEAKT PDALPEGLVR ELPSADEFQK PPTEATEGTV DDLEDLRKQL
     EALNS
//