ID A0A498I9M0_MALDO Unreviewed; 769 AA.
AC A0A498I9M0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Tetratricopeptide repeat protein 38 {ECO:0000256|ARBA:ARBA00019992};
DE EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
DE Flags: Fragment;
GN ORFNames=DVH24_040766 {ECO:0000313|EMBL:RXH79619.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH79619.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXH79619.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXH79619.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000710};
CC -!- SIMILARITY: Belongs to the TTC38 family.
CC {ECO:0000256|ARBA:ARBA00005857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXH79619.1}.
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DR EMBL; RDQH01000339; RXH79619.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498I9M0; -.
DR STRING; 3750.A0A498I9M0; -.
DR Proteomes; UP000290289; Chromosome 13.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:InterPro.
DR GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd03185; GST_C_Tau; 2.
DR CDD; cd03058; GST_N_Tau; 1.
DR CDD; cd05804; StaR_like; 1.
DR Gene3D; 1.20.1050.10; -; 2.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR045074; GST_C_Tau.
DR InterPro; IPR045073; Omega/Tau-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR033891; TTC38.
DR PANTHER; PTHR16263; TETRATRICOPEPTIDE REPEAT PROTEIN 38; 1.
DR PANTHER; PTHR16263:SF4; TETRATRICOPEPTIDE REPEAT PROTEIN 38; 1.
DR Pfam; PF13410; GST_C_2; 2.
DR Pfam; PF02798; GST_N; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01152; Main.3:_Omega-_and_Tau-like; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 2.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 2.
DR PROSITE; PS50404; GST_NTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..117
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT DOMAIN 136..215
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 221..352
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RXH79619.1"
SQ SEQUENCE 769 AA; 86228 MW; 7550524BBE160F1C CRC64;
WVQWFPSLRG VAAAEGDEAR KAAVEQVAEG LDKMEEAFQK TSKGKDFFSG DKIGYLDIAF
GCFLGWLRVT EKMNGIKLLD EAKIPGLAKW AEKFSADPAV KDVMPETDKL AEVAKIVTAR
LRAAGASNRG LIMGESDVKV LGMAPSPFVM RARIALNLKS VDYEFLQETF GSKSELLLQS
NPIHKKVPVL IHGDKPVCES LVIVEYIDEV WASGPSILPS DPYDRATARF WAAYISEKWY
PSMKGIGFAQ GEEAKKAAIE QVTEGLALLE EAFEKSSKGN VFFGGDEIGY LDIAFGCFLG
WLRVNEKLHG IKLLDQTKTP GLVKWADKFC AHAAVKDVMP ETDMLVEIAK ILAAKARAAA
APPPTSSDAC VSAINAFYDQ VGFKLSAAAA HDDQCVLANI LAAYFLSSDP SRAPSHLQAA
KSRLEQATPY EKAVFDAVNC LISKDRDDDV AFELHSKLLK SFPRDLASLQ RAQVLCFYMA
RPDLSLDLVQ QTMLNAVEDN FLAVIFRASC MSIEINKCDC WVQHNMCHVL QYNCRFKEAA
ELMEECSPSW DLCSSFMFTH NWWHVALCYL EGHAPIQRIR DLYDHFIWKE LEKPDAPRPE
VYLNALGLLL RVHARGEMDA FKDHLKTVEN CVTDQANWYL DWQFDMLVLW ALAYTGEISK
AEELLKGLKP RITKMNEKKQ QFMQNAILLT EATYEYGKGN GKQALELLGP DFDADKLQAI
EVLKKRIKTR EGIPFLWRLL ERGYKLTGRD EEAATASEEA KRLEKAYFP
//
