ID A0A498J4W5_MALDO Unreviewed; 2520 AA.
AC A0A498J4W5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=UvrD-like helicase ATP-binding domain-containing protein {ECO:0000259|PROSITE:PS51198};
GN ORFNames=DVH24_035422 {ECO:0000313|EMBL:RXH90658.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH90658.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXH90658.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXH90658.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXH90658.1}.
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DR EMBL; RDQH01000335; RXH90658.1; -; Genomic_DNA.
DR Proteomes; UP000290289; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR045529; DUF6469.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR039904; TRANK1.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR21529; MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2; 1.
DR PANTHER; PTHR21529:SF4; TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF20073; DUF6469; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Helicase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2214..2238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2291..2310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 920..1309
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT REGION 2442..2520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2445..2470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2471..2485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2489..2503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2504..2520
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 941..948
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 2520 AA; 286382 MW; F766807AB05D2177 CRC64;
MVSESSKNFP ASPVNMVTKS SKNFPCFGRE RVSETMSTSD RFMDTVFSWS LEDIFNDNLY
KNQVKKIPES FDSALHYFGS YSFPLLEETR AKVQSSMETI DRAPFAEVVA FNESKSKFDE
TWIYNIKVDE WRNRFSERGK EPYKTLPGDL FVLADAKPET VSDLQRVGRS WTFVSVTNIT
ENKISENKRE DEFNDEIIET EIKEFKVKAS KRFQVNDNKS TPASVFVVFL VNLITNSRIW
AALHMFGNLK IIKDVLCTHS VAQENYPPSY EMNADIRDKL LFECSSSGLN ESQTGAVLAC
LEMLFCDSKS STLQLIWGPP GTGKTKSTAT LLLTLLRMNC RTLVCAPTNV AVTEVASHLV
EMVTEAESSA LFCPLGKILL FGNKEGLKVG SDIEDIYLDH RVESLFECLG PVTGWSSCSS
SMIGLLEDCV SHYHIFLENE LAKEKKQNGD GELVRKGCGS ETEVSKGKGK SFLEFFRERF
VPTALPLKCC IATFCTHISQ DYISAQNFQD MISLLGLVDS FGLLLLQGNV DSEVLEELFS
RSEVEDVPEP VGDTFHLYMK RRKCLSVLQW DVSKEKLSIG VISPYAAQVA ALQDKLGQKY
DKLDGFKVKV NTVDGFQGGE EDIIIMSTVR SNQHHSLGFI SNPQRVNVAL TRARHCLWIL
GNERTLCGSE SVWEDLVLDA QNRRCFFKAD EDKDMAKAIL EAKKELDQFD DLLNADSLLF
RSSRWKVLFS DNFLKSFRKL KSIQLKKSVL NLLLKLSGGW RPKKKNVQTS SGSSSILRQY
KVGGLYIVCT IDIAKELKYI QVLKVWDILP LEDIPKLVNR LASIFKRYTD DFINRCNEKC
LEGNLEVPKC WPTSLDVPRF KDLSAAETDS DFVGDASDGR SYVENSQVSE SLLLMKFYAL
SSGVVNHLLS DREGKELDLP FEVTDQEMEI ILYHKSTFIV GRSGTGKTTV LTMKLFQNEQ
CHHLAEKGCG SSSNSMAEPS SSATQGRTLH QLFVTVSPKL CFAIKQHVLH LKRFACGGSD
STEKVSIDMA DFDEEEFQFK DIKDSFQDIP PDSYPLVITF HKFLMMLDGT LTNSYFERFL
DPTTLTHGQL RSSRSVALQA FIRTKEVNYE RFSSSYWPHF NMQLTKQLDA SRVFTEIISH
IKGGLGAIEA VDGRLGREDY VQLSEGRVSN LSKQKREVIY DIFQAYEKMK LESREFDLAD
FVIDLHRRIR HEKFVGDQMD FVYIDEVQDL TMSQIALFKH MCNNVEDGFV FSGDTAQTIA
RGIDFRFQDI RHLFYKKFVL ESRGNKHQER KEKGQISEIF HLTQNFRTHA GVLKLSQSIV
ELLYRFFPLS IDILKPETSL IYGEAPVLLE SGEDENAIIR IFGNSGIDNS NIVGFGAEQV
ILVRDVGAQK EIFKIVGKQA LVLTIVECKG LEFQDVLLYN FFGSSPLKNQ WRVIYDYMKE
QDLLDSTLPQ RFPSFSEAKH NILCSELKQL YVAVTRTRQR LWFCENVEEL SKPMFDYWKK
KCLVQVRQLD DSLAQAMQVA SSPEEWKSRG IKLYHEHNYE MATMCFERAG DTYWERRSKA
AGLKAIADRM RTSNPSEANT ILKEAAEIFD AIGKADSAAR CFSDLGEYER AARIYLDKCG
DLERAGECFS LAGCYQDAAD VYAKGNFFSE CLSVCAKGKL FEMGLKYIKY WKQHPIKDSA
VARRGEGMDE IEQAFLESCA LHYNKLKDNR SMMNFVRAFH SIISMRNFLK EHAGLDELLL
LEEGFGNYLE AAEIAKLKGD IILEADFLEK AGKFREASLH ILFYVLANSL WSYGSKGWPV
KQFSQKEELL SKAKSCAKNE TESFYEFVCT EVEVLLNEQS NLFVLKNHMN ACQRHSSVGG
EILSSQKILD AHLSSSADKY VWEEMLVDDL IKCSANGISE NQVSMDSLIY FWNFWKDKIA
HIFEYLRCLE TQEVSEYKSY GEFCLNYLGV WRMYHNLSPV YVLLIPDADW VCGLNKRYFR
NQGKLVSIDA HQLASAARNY WSSELLSVGM KVLDKLEKLY KFPIKNADSV FCRSRCLTYI
CEVSVYLLQS KCLTLRYHDA ERLHKCVTFS IESIVPLVFP LDWRNSLREN LISLRQTDAS
KNVLKQVIQE FTRSKNELSW GQIGKLVMVI LGTGKLTNEL YEKLVRKLDC NPPWQVFIEN
LCGNIERGNT SQEPKEVSVM LRFHEALAGT YNVNWRAVKD YITPGCFLYL LERLLIWATC
FQGYAITTSS CFIEWLIYQG EDTSLSLRGA DVRPSLDGVL RFVIDVVRDC IFNKVDMVEW
IKKSIKDWMN YYSLLMVRLV VVLCLVYVNF GIGLDLLHDL LGRNYITEQL PSEFYNALKS
RSGKSVRLDV NVLAAALKKV GNTLVIASFG TNCSRWLCSD AVFVDMMANQ SRDDIFRKLF
PKPPVLKASE AGSSSRVLCA TNSEEGKTGA ALDKPCDAGE SHTIGEGNCE SNKSPKSQQT
DVASVPSETR DSHNIGEENR IRNESDLLAD AASGSQCTGN KGKTKNKNKN KRGKNKKGRK
//
