ID A0A498JLG0_MALDO Unreviewed; 2335 AA.
AC A0A498JLG0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Clp R domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DVH24_008405 {ECO:0000313|EMBL:RXH95905.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXH95905.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXH95905.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXH95905.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXH95905.1}.
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DR EMBL; RDQH01000332; RXH95905.1; -; Genomic_DNA.
DR STRING; 3750.A0A498JLG0; -.
DR EnsemblPlants; mRNA:MD06G0103100; mRNA:MD06G0103100; MD06G0103100.
DR Gramene; mRNA:MD06G0103100; mRNA:MD06G0103100; MD06G0103100.
DR Proteomes; UP000290289; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd00060; FHA; 1.
DR CDD; cd00333; MIP; 1.
DR CDD; cd09122; PLDc_Tdp1_1; 1.
DR CDD; cd09123; PLDc_Tdp1_2; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.30.70.2330; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR014905; HIRAN.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR010347; Tdp1.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF185; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF08797; HIRAN; 1.
DR Pfam; PF00230; MIP; 1.
DR Pfam; PF06087; Tyr-DNA_phospho; 2.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00221; MIP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 73..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 358..431
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1473..1638
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1952..1974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1952..1971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 775
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT ACT_SITE 1199
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT BINDING 777
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT BINDING 1201
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT SITE 1227
FT /note="Interaction with DNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-3"
SQ SEQUENCE 2335 AA; 255326 MW; 0C59459B35A14FDD CRC64;
MAESEPVTPS ASAPATPGTP LPLFSGPRVD SLSYERKSMP RTKCFPVNAT AWGQSPTCFN
EFPTPTVSLT RKLGAEFVGT FILMFAASAG PIVNQKYNGA ESLIGNAACA GLGVMIVILS
TGHISGAHLN PSLTIAFAAL RHFPWVQVPA YIAAQVSASI CASFALKGIF HPYISGGVTV
PTVSTGQAFG LEFIITFNLL FVVTAVATDT RALGELAGLA VGATVMLNIL IAGPSSGGSM
NPVRTLGPAV AAGNYTKLWI YLVAPTLGAL AGAATYTAVK LREDEVDAPV REARSFHLSS
DYGGEVKRCP IHRKRPRPPR SEASTAVSVH VKQLDVPLTC PETGSPVDSI CLQPDRPYTI
GRSNRGCHFV FADRRVGKKH CQIIYNSFDR KLYVIDGALI SVPQFRNRLE LEECCNVRVS
LNGVFVNGIR VREGVAVELS DGDRVSLGCS TENCCNPIRI GFVVNKIVCE DQIVQSFDNP
QGPVKPLCVS CPWGRKRVFA SRAEGSPSSI VGRANFLLSE CRHILLSNDP ISYIRKCCRY
SFENGFIRSN DIGESPGLDT DRLPLNGEKS LLCQTSHIDC DVKNKMQFTS VMHQCENVVA
SEPNGVILHK QDNAQVPSET AVADGNLETS SFNFTGREDP PNCDGIVKNK TRCRNVASQP
GKNFYLNRLS FMGHNSSTSS QDSVISLPEL LYPVQSISQM FIATFTSDIL WFLSSCEIPS
HLPVTVACHN TERCWSSSPN KRTSSPYPDF PKYPPFPEAI AFGNDRKRHG IACHHPKLLV
LKRDDSIRVI ITSANLVSTQ WNAVTNTVWW QDFPCRSAPD YTSLFTQFHD GETNQDSKTD
FASQLAGFMA MLLTDVPSQA QWIVDLTKYD FGGATGHLVA SVPGVHSYKT PFMLDSRHFG
LADHGASSGA KFLGSVEASV VGLSYLFRNA KDSNGAKLKK LASFLRKSCE HAKALSIVLT
RNTNVPADAN AVNIVVPDSN EGDSVQLGFL PRNVAKWVSP LWDIGLFSFS GYICPKEALT
AALGGGNSKK VQLILHVSQG PKFEDISNIM ESQHIFALCS LIGAVQRCTG LWRLQEVLGQ
YNWPESLDSD FVYGASSIGS INAKFLAAFS VAAGKKSLEF ESEESDPEWG CWSASQESKS
PSIKIVFPTI KRVKNACNGI FPSKRILCFS EKTWQRLRTI DILHDAIPHP YDRVGHPMHS
KVARRRFHSK TDGSSFGWVY CGSHNFSAAA WGRPINGPFG LNMNGLGKAN STLGQMLHIC
NYELGIIFTF PPTDTDGSAN KNSAKLDNIV LPFIVPAPKY RRGDRPATGK AMREALAELT
EQERQKLLEA ATIEEIMEET PDEDEVVEAD DYVAEEKEEE KAYAKILWSQ VDSSESMSSS
SSSSVLIPSL QWWTPSLNSS TSNCCCTQFL RYDRSRSRSS GGGRQVFSLY PIRLANPSPP
FASSFLSPFK ARTFPTGPTG RRKTKLRIVA AVFERFTERA VKSVIFSQRE ARALGRNMVF
TQHLLLGLIA EEEQHRHLHP NSHGFLGSGI SINQAREAVR AIWHHHSQSQ TSASAEVDPS
SRAASSSATD VPFSISTKRV LEAALEYSRA RAHNFIAPEH IAIGLFTADD GSAGQVLKRL
GVDVNQLLAE AASRLQVELV KDGREPSGGF QKSLSKKSIA SGKKKDKSAL DQFCVDLTAR
ASEGLIDPVI GRDTEVQRII QILCRRSKNN PILLGESGVG KTAIVEGLAI SIAQADVPAF
LLEKRVMSLD IALLMAGSKE RGEMEARVTT LLSDIRKAVH TLIESGTVGQ RNKGSSLDIA
NLIKPPLGRG QLQCIAATTA DEYRLHLEKD KAFARRLQPV WINEPSQDDA VRILLGLREK
YEAHHNCRYE PEAIIAAVYL AARYIPDRYL PDKAIDLIDE AGSRARMDAF KRKREQQICI
LSKSPDDYWQ EIRTVQAMHE VVLATELKNS DASSVDDIRE PSSSSSTSGD EPAVVGPEDI
AAVASLWSGV PLQQLTADDR MLLVGLDEKL RKRVVGQEEA VAAISRAVKR SRVGLKDPDR
PMATLLFCGP TGVGKTELTK ALAASYFGSE EAMLRFDMSE YMERHSVSKL IGSPPGYVGY
GAGGTLTEAI RRRPFTVVVF DEIEKAHPDI FNILLQIFED GHLTDAQGRR VSFKNALVVM
TSNVGSTIIA KGRQSSIGFL LADDEVTSYA GLKATVMEEL KTYFRPELLN RIDEVVVFHP
LQKAQMLEIV NLMLQELKKR LMSLGMGLEV SESVKGLICE QGYDRFYGAR PLRRAITSII
EDPLSEALLA GGYKPGDTVV IDVDATGNPF IRNGSDQSVR LSNSSVQHPS CNIIR
//