ID A0A498K7U6_MALDO Unreviewed; 379 AA.
AC A0A498K7U6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Squalene cyclase N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DVH24_038623 {ECO:0000313|EMBL:RXI04349.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI04349.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXI04349.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXI04349.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXI04349.1}.
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DR EMBL; RDQH01000329; RXI04349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498K7U6; -.
DR STRING; 3750.A0A498K7U6; -.
DR Proteomes; UP000290289; Chromosome 3.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031559; F:oxidosqualene cyclase activity; IEA:UniProt.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11764:SF58; BETA-AMYRIN SYNTHASE-RELATED; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 123..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 99..243
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 255..354
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 379 AA; 42487 MW; 6B1DAF5F71E1ED2B CRC64;
MWRLKIGDGA DGPYLSSTNN FLGRQTWPFD PHAGTLQERA EVEEARQNYL KNRFQVKPSS
DFLWKMQFLR EKNSKQAIPP LKINEGDEVT HEIATAAMKR AVHFNSALQS SHGHWPAENS
GPLFYLLSLV MCLYITGHLS VVFSVEHRKE IKRYIYNHQN KDGGWGLHIE SPSNILRLLG
EGPDGGEENA MARGRKWILD HGGVTNILSC VKAWLSILGV YDWSGCNPIP PEYWMLPSFL
PMHPGLEVGK SASHMVHGLA TAGKTYYNCP AMRNGVNSLL ASQGDDSGWG ESYLSCLRKK
IIPLEGRRSN LVQTAWALMG LIHAHQAERD PTPLHRAAKL LINSQMEDGG FPQQVAYRLH
ICNTFPLMAC VIWSGSLDF
//
