ID   A0A498KA77_MALDO        Unreviewed;       660 AA.
AC   A0A498KA77;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=GTPase Der {ECO:0000256|ARBA:ARBA00020953};
DE   AltName: Full=GTP-binding protein EngA {ECO:0000256|ARBA:ARBA00032345};
GN   ORFNames=DVH24_003906 {ECO:0000313|EMBL:RXI03254.1};
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI03254.1, ECO:0000313|Proteomes:UP000290289};
RN   [1] {ECO:0000313|EMBL:RXI03254.1, ECO:0000313|Proteomes:UP000290289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC   TISSUE=Young leaf {ECO:0000313|EMBL:RXI03254.1};
RA   Hu J.;
RT   "A high-quality apple genome assembly.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. EngA (Der) GTPase family.
CC       {ECO:0000256|ARBA:ARBA00008279}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXI03254.1}.
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DR   EMBL; RDQH01000329; RXI03254.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498KA77; -.
DR   STRING; 3750.A0A498KA77; -.
DR   EnsemblPlants; mRNA:MD03G0144800; mRNA:MD03G0144800; MD03G0144800.
DR   Gramene; mRNA:MD03G0144800; mRNA:MD03G0144800; MD03G0144800.
DR   OrthoDB; 211919at2759; -.
DR   Proteomes; UP000290289; Chromosome 3.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   CDD; cd01894; EngA1; 1.
DR   CDD; cd01895; EngA2; 1.
DR   Gene3D; 3.30.300.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   HAMAP; MF_00195; GTPase_Der; 1.
DR   InterPro; IPR031166; G_ENGA.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR016484; GTPase_Der.
DR   InterPro; IPR032859; KH_dom-like.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   NCBIfam; TIGR03594; GTPase_EngA; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43834; GTPASE DER; 1.
DR   PANTHER; PTHR43834:SF2; GTPASE DER; 1.
DR   Pfam; PF14714; KH_dom-like; 1.
DR   Pfam; PF01926; MMR_HSR1; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51712; G_ENGA; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT   DOMAIN          366..546
FT                   /note="EngA-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51712"
FT   REGION          70..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..93
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  72615 MW;  5871783BE4B1FCA4 CRC64;
     MAAPSELLCY RGTTTSPSLS KTLSLLSSPF PIPKYFSRGL RTPSLSLHTS LHTLPCFVSR
     LPANEFNISS TADDQQQQEG DGEEEEELVD ESDGGGGELL TADVDDLEED ARYLVEEFSS
     SLSTQLRIED DKDDQEKVGR KQRNQKSTVK TIPDHLLPRV AIVGRPNVGK SALFNRLVSG
     NKAIVVDEPG VTRDRLYGRS FWGDHEFMVV DTGGVLTVSK SQANVMEELA ISTTIGMDGI
     PLASREAAVA RMPSMIEKQA TAAVEESSVI IFLVDGQAGL TAADEEISDW LRKNFSDKYI
     ILAVNKCESP RKGIMQASEF WSLGFSPLPI SAISGTGTGE LLDLVCSGLK KNEDPEDFAE
     QEEYVPAIAI VGRPNVGKSS ILNALVGEDR TIVSPVSGTT RDAIDMEFTG PDGQKFKLID
     TAGIRRRAVV ASSGSMTEAL SVNRAFRAIR RSDVVALVIE ALACITEQDC KIADRIEREG
     KGCLIVVNKW DTIPNKNQQT ATYYEQDVRE KLRILGWAPI VYSTAIAGQS VDKIIDAAST
     VEKERSRRLS TSVVNQVVQE ALAFKSPPRT RGGKRGRIYY CTQAAIRPPT FVFFVDDSKL
     FPETYRRYME KQLRSDAGFL GTPIRLLWSN RRKTEKEEGK AATRAQANLV PRDRKLELAT
//