ID A0A498KDX9_MALDO Unreviewed; 1990 AA.
AC A0A498KDX9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN ORFNames=DVH24_038006 {ECO:0000313|EMBL:RXI03732.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI03732.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXI03732.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXI03732.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXI03732.1}.
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DR EMBL; RDQH01000329; RXI03732.1; -; Genomic_DNA.
DR STRING; 3750.A0A498KDX9; -.
DR Proteomes; UP000290289; Chromosome 3.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1180..1416
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1572..1969
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 335..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1990 AA; 215813 MW; 9A489944B2B598E6 CRC64;
MWTNVFKIFN RFPLFINLTC WIRKANNNLT PLYWELGREF SVIVFWVEVT VWSYESVAYL
RGNLGGFHQV SWFQFLPHES ELIPLPDKSA KDAATRLVLS SHVQLQKDGF LSTWTNSFVG
PWDPSQGVHN PDEKIKLWLF LPGRHSTVAD SAQAAVSKLR VVASGLWMSP GDSEEVAAAL
SQALRNRIER ALSGLAYMRF GDVFSKFHPS ESEELLRKGQ PTVEFIFAAT DEGIFVHALV
SAKHVRALSN GDLERRLKHS SKNSGCGLPV IVSPHGMCGR LTGCCPSDLV KQVSSKFKTG
NGFIGLANHA SQGSGCQLRG QNCYVEVTLG CPRPGSDRSL QANSNSLRNT GKHNLSESPA
LGRGDQKLAL DNSSVYEKTF VYPAEAVLVP ALQVARSSLK SSENIEPVED WNETDGIRTQ
RWYNSSSNSN SSSISSISSS SSDSDYTMAT GASELEADAD SLTCRQSGLS FNDRLGNDIS
KSGFKRPRAG MADSFAEVGT ATSASLQDAY NSDFSSMEVS NSAIPGLANE QIGSHWDWDV
DDRDGTDIHA LINEFGDFGD LFEDDVLPFG EPPGTAESQS LMFSAPDPGD VVDNPVGMMD
VSDQLLLSDG FASFESFIPP PPAAMEEPLI KNQEVINSVM SSAPVNCSSA SNISEFDHII
KAEALMTFAP EYGAVETPTS EVSSSVFRSP YLPKSRKAES SNSNSSIYTY GPTPPSSCFD
GSDEKTGMPI NSKSCPGKKD ASNIIRSKNY YTHVESGKDQ QDGRLLTGSN GIVLAHDGAA
SSPFPILNST NAVKVAQRKI TEGRFESENP FLSMRTILAT EVECILFQTS MCRIRHTLLS
SSSLSSTGFS SLPGDQSVMP ENMSGKYEAK RKESIPVRIA GDIDRGMTDG HPNAPVGVWR
TVGAPRAPKP TSSSSKEISP SLPHSSFNEE SLLSYGQRQP LQELLDGFTL LVQQATSFVD
LALDSDCGDG PYGWLALQEQ WRKGFSCGPS MVHAGCGGTL ASCHSLDIAG VELVDPLSAD
VHASSVISLL QSDIKTALKS AFGILDGPMS VTDWCRGRNQ SGESTLDGYS AESAISECRD
VAPSIGEPLS PSPSSSAGST YIKVSSAMDG VKAEETSQRR SNQDNCTSES DLQTCSRLRP
TLFVNPLPAI LVGYDDWLKT SASSLKHWEK APLEPYALQK PITYSVVCPD IDPLTSAAAD
FFQQLGTVYE TCKLGTHLPQ IVGNQMEVDS GRRPSPGFVL LDCPQAMKME SRNASFVSSI
SDYFLSLSNG WDLTSYLKSL SKALRGLKLG HCLSTNAKEG SSGPSTVIYV VCPFPEPIAV
LQTVIESSVS IGSVIFQSDR ERRSLLHSQV SKALSYSATV DEASISNILV LSGFSIPKLV
LQIVTVDAIF KVTSPSLNEL VILKETAFTV YNKARRISRG ASSDAVQSSS LSNRPHAVLT
QMSSPTPGMW KDCVGSRITG HSLPREGEID ASLRTGGWDS SWQTTRSGAV SCDPNRIGDF
FPQDETRYMF EPLFILAEPG SLERALSPLA FGNLSLESSK PLSDDSSGGF LQNASLGGSA
DSGSGSQDGS ELDKTPSLHC CYGWTEDWRW LICIWTDSRG ELLDSHIFPF GGISSRQDTK
GLECLFVQVL QQGCQILQAC SSDTGVAKPR DFVIARIGSF YELEYQEWQK AINSVGGSEV
KKWHLQLRRS VSDGMSASSN GPSMQQQEMS MIQERTLPSS PGPLYGSSHS KMSGYMKGGL
GQPSVRKQLM GTQLMDSSRS LLQWVQSISF VTIAIDHSLH LVFQADTQSP GAQGAVGMGS
SAYLEGFTPV KSLGSTPASH ILIPSPSMRF LPPTPLQLPT CLTAESPPLA HLLHSKGSAI
PLSTCFVVSK AVPTVRRDRR SNLKEEWPSS LLVSLIDHYG GNSFSQDKLM RGNTKQAGRS
PSLEARELEF ETHVILESLA TELHALSWMT ASPAYLERRS ALPFHCDMVL RLRRLLHFAD
KELSRHQEKA
//
