ID   A0A498KIJ1_MALDO        Unreviewed;      1381 AA.
AC   A0A498KIJ1;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=DVH24_018276 {ECO:0000313|EMBL:RXI06234.1};
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI06234.1, ECO:0000313|Proteomes:UP000290289};
RN   [1] {ECO:0000313|EMBL:RXI06234.1, ECO:0000313|Proteomes:UP000290289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC   TISSUE=Young leaf {ECO:0000313|EMBL:RXI06234.1};
RA   Hu J.;
RT   "A high-quality apple genome assembly.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXI06234.1}.
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DR   EMBL; RDQH01000328; RXI06234.1; -; Genomic_DNA.
DR   STRING; 3750.A0A498KIJ1; -.
DR   Proteomes; UP000290289; Chromosome 2.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR029005; LIM-bd/SEUSS.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR10378; LIM DOMAIN-BINDING PROTEIN; 1.
DR   PANTHER; PTHR10378:SF19; TRANSCRIPTIONAL REGULATOR SLK2-RELATED; 1.
DR   Pfam; PF01803; LIM_bind; 1.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000290289}.
FT   DOMAIN          17..181
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          1229..1381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1233..1381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1381 AA;  155045 MW;  52EEDA62A7FA6684 CRC64;
     MANQFVPSSS FRTTPSCTYD VFLSFRGEDT RYNFTDHLHH ALVRHGIRTF IDHSELPIGE
     EISPTLLEAI ENSRISVIIF SENYASSRWC LDELVHILKC KESKGQMTRP IFYKVNPSDV
     RHQRNSYGAA FADHSCNNLE KVQRWRTALT EAANLKGATL KEGEYGTKKV RGIIVNLPEP
     YEIPLHPKSF LKMVNLEFFI NRNAHFSGRV DYLPNSLRLI EFGGRFKFDQ KHTYELNLQS
     NFRPRHLVKF DVAYSSIRQL KGFKNLAKLT SMDLSGCKFL EKIPDLSGSP NIIKLDLRDC
     TSLVEVDDSV GFLDKLERLY LSGCSKLTRF ATRLGLRSLK GLYLDGCTRL ERFPEIEKDK
     MKSLSHLFIE DSGIRELPSS IAYLTGLKWL LASGCELRNV PDLSGSPNIE ELELRDCKSL
     VEVHDSVGFL DKLEDLDLSG CSKLTRFATR LGSRSLFSLS FEGCRRLESF PEIEGKMESL
     YRLNIEKSGI RELPSIAYVP RLCSLNASGC ELQNIQLLPF GKKVKFDEVS SWCINLHLEG
     CNLSESDFLV PLDCWSALTA LNLSRNNFVT LPDCISEVVN LETLFLRGCK RLREIPVLPS
     KLKALELDDC TSLEKIPKLP LRLKKLSLCN CKRLQEIPVL PSELEELGLD NCTSWEKFPK
     LPPSLRKLSL DDCTSLEKIP KLPPSLEKLS LCNCSGLSGD EVAKNLLNEV AKLQNRWLNL
     QMHAMDPHSE LDTIYPGNEV PKWFSYTSNH PTTIQPLPGY EWDEYERKEE FVGGSEYRFE
     IPLKLLVGET LFGLALSFVL EPPTDGFDIY RIIINRKKLV IRDESTDIKE THVRVVIAQI
     WWQEQQGDIC PVVFRFKKEC AIKSCGVHRL LRNEDELRDL KEARRAQLQQ REQQQFQQPM
     QPVSSIKRPY DGGVCARRLM QYLYHLRLRP AVSSLDNSIA YWRRFVTDYY SPRAKKRWCL
     SSYDNVGHHA LSVLPQAAMD AWQCDICGSK SGRGFEATFE VLPRLNMIKF GRGVIDDVIF
     LGVPRECGFP SGEMMLEYGY VSLISYEQLR VVREGQLRII FTQDLKKCQS TIAESGSDGI
     SQQDLQTNGN MVPTAGRQLA ESLELQSLND LEGLKVYPRH ATAAKLHMQK MQEMEQLASA
     QGLSTDRNTL NKLMALHLGL NNQMNNHHQM VGPGAMSGAA QAAYQNLLLR HNSMNSNANC
     LQQEASSSFN NSNHSPSSTF QGAAALIPGS MQNLPGSALS SPHLPSRQPQ QLQQRSLSSN
     SLLQQTHSTG SQGNQALQQQ QMIQQLPQEM PNNSGGGQQS LPCPSANGSV GRNGVSFGGN
     NPAAAPSTSN ASGSHGPAPS RNNSFKATAN SDNSTGGGGN NTYNQRAPDL PLNLTNCFTG
     L
//