ID A0A498KJM4_MALDO Unreviewed; 745 AA.
AC A0A498KJM4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Mechanosensitive ion channel MscS domain-containing protein {ECO:0000259|Pfam:PF00924};
GN ORFNames=DVH24_025740 {ECO:0000313|EMBL:RXI06604.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI06604.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXI06604.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXI06604.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXI06604.1}.
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DR EMBL; RDQH01000328; RXI06604.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498KJM4; -.
DR STRING; 3750.A0A498KJM4; -.
DR Proteomes; UP000290289; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016688; MscS-like_plants/fungi.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR PANTHER; PTHR31618:SF26; MECHANOSENSITIVE ION CHANNEL PROTEIN; 1.
DR PANTHER; PTHR31618; MECHANOSENSITIVE ION CHANNEL PROTEIN 5; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 532..590
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT REGION 25..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..115
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 86166 MW; CEA6AA2D08AE175A CRC64;
MNEKLVSSVS TMEVQKSNTD HVVVTIDQPN PKLKQSPQAD PNISIPQPLS SAKTLRRLNF
SKPRSRFEEI KYPLPPKTIH ESEQLQPLNP YQDNNSSTDE DDDEDWYENE EDEEENNDGK
QGKHLKRRKR KINKRAVIEW TLFLIIMTCL VCSLRLDSLK NNVKWGLEIW KWCVMVMVMF
CGRLVSGWVV GFLVFIIERN FMLREKVLYF VFGLRKSFQN CAWLGLVLGA WMIMFPDKHN
KVLKKIFCAL IAVLIGATIW LLKILFVKVL ASSFHVATFF DRMKESVFHH YILEALSGPP
LDEDERELPQ RRFQASKSLP ARLRDKSHAV SRSYRREGSR RIDMEKLRRL SMASRATAWS
VKRLVNYVRS SGLSTISRTI DDFGNAESEI TSEWEARNSA QRIFKNVAKP GAKYIEEDDL
LRFLKSDEIH TIFPLFEGAI ETGKVTKSSF RNWVVHAYIE RKALAHSLND TKTAVHQLHK
LASAIVIVII TVVTLLVMGL ATTKVIFVVT SQLLLVGFMF QNMCKTVFES IIFVFVMHPF
DVGDRCVVDG VQMVVEEMNI LSTVFLRYDN EKIFYPNSVL LTKPISNFRR SPDMADSIDF
TIDVSTPVDD VSALKKAIQL YIDSKPKYWS SKHSVIVKEI ENVDKMKMML CVQHTMNHQN
YGEKSARRSE LVFELKKIFQ NLGIKYHLLP QEVNLPQFNA SNERKLLCFH CTTVMLINTI
MRLGVQFLVK HTMKLLVEIY GSRRW
//
