ID A0A498KKM9_MALDO Unreviewed; 884 AA.
AC A0A498KKM9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=DVH24_018367 {ECO:0000313|EMBL:RXI06325.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI06325.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXI06325.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXI06325.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXI06325.1}.
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DR EMBL; RDQH01000328; RXI06325.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498KKM9; -.
DR STRING; 3750.A0A498KKM9; -.
DR Proteomes; UP000290289; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..747
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 750..881
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
SQ SEQUENCE 884 AA; 100390 MW; 656E8FC347ACC8EC CRC64;
MFLSIQSPPM DRRNSIPIFI LIVSLIACFL IRNADVSDLV DFQIIGPPRS YDGAVLNSVS
SSQLELPVFY QTRDGDVLNW ESGESRALQP LGSQQKELEV VSRSPSRRLH SHTEDEPRTA
LVALLDGTIQ LVDRNSMGVR WAFDSGPPIY SSYQAQSSSG YFIYCGDDWD LYEHSDHFGR
RKIPSTIAEY VDKKTPKVEE DGSVTLGHKK VTFFEVGLFT GKVYRSYTLS EDHVRDRKKF
VKPSLINGNA GEPRIVFFRI DYYLVSYHPY SEEVSWNMTI AEIRAAIPCK DIENLIRGSK
TGSQIALPFD CQSKALVKRE RDHGSLEHQQ ADTVVKRSAS DLVVPLNKKD LVVPSEPEVH
NMFLHWSKAF ALAFLFVILM GFVVYYFVFL VNVQKPDPKA SPSKRKKSRK LGKNGIVERK
EEGVLSQDEE ALTHTEGDNK ILPFLNKLFD GGTNGRRIGK LVISSTEISK GSNGTIVLEG
VYEGRPVAVK RLVLAHHDMA FKEIQNLIAS DRHPNIVRWY GVDYDKDFVY ISLERCICNL
DDLIQICPNS SQNPVAGEED AKRVLIENEV RLKSLKNIMS DVNLWKIDGF PSLLLLKLMR
DVVSGLVHLH EMGIIHRDLK PQNVLLIKER TLCAKLSDMG ISKRLIGDMS SLGCGSSGWQ
APEQLLHGRQ TRAVDMFSLG CLLFYCITGG RHPFGDQLER DINIVKNQMD LFLVEHIPEA
VDLISRLLNP DPEIRPKVSE VLLHPLFWNS ETRLSFLRDS SDRVELEDRE ANSGVLRALE
SIAPIALGGK WDQKMEPAFL TNIGNYRRYK FDSVRDLLRV IRNKSNHYRE LPNQIQELVG
PVPEGFDFYF ASRFPRLLIE VYKVVCQNCR EEECFGKYFK SNAD
//
