ID A0A498KN65_MALDO Unreviewed; 739 AA.
AC A0A498KN65;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=adenylate kinase {ECO:0000256|ARBA:ARBA00012955};
DE EC=2.7.4.3 {ECO:0000256|ARBA:ARBA00012955};
DE AltName: Full=ATP:AMP phosphotransferase {ECO:0000256|ARBA:ARBA00031517};
GN ORFNames=DVH24_022715 {ECO:0000313|EMBL:RXI08571.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI08571.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXI08571.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXI08571.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + UMP = ADP + UDP; Xref=Rhea:RHEA:24400,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:456216; EC=2.7.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00001331};
CC -!- SIMILARITY: Belongs to the adenylate kinase family.
CC {ECO:0000256|ARBA:ARBA00007220}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXI08571.1}.
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DR EMBL; RDQH01000327; RXI08571.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498KN65; -.
DR STRING; 3750.A0A498KN65; -.
DR Proteomes; UP000290289; Chromosome 1.
DR GO; GO:0004017; F:adenylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004127; F:cytidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0009041; F:UMP/dUMP kinase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0009451; P:RNA modification; IEA:InterPro.
DR CDD; cd01428; ADK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR HAMAP; MF_00235; Adenylate_kinase_Adk; 1.
DR InterPro; IPR000850; Adenylat/UMP-CMP_kin.
DR InterPro; IPR033690; Adenylat_kinase_CS.
DR InterPro; IPR046848; E_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR045215; PPR_prot_At1g15510.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR006266; UMP_CMP_kinase.
DR NCBIfam; TIGR00756; PPR; 4.
DR NCBIfam; TIGR01359; UMP_CMP_kin_fam; 1.
DR PANTHER; PTHR24015; OS07G0578800 PROTEIN-RELATED; 1.
DR PANTHER; PTHR24015:SF2028; REPEAT-CONTAINING PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF00406; ADK; 1.
DR Pfam; PF20431; E_motif; 1.
DR Pfam; PF01535; PPR; 3.
DR Pfam; PF13041; PPR_2; 3.
DR PRINTS; PR00094; ADENYLTKNASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00113; ADENYLATE_KINASE; 1.
DR PROSITE; PS51375; PPR; 5.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REPEAT 338..368
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 371..405
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 441..471
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 472..506
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 539..573
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 240..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 83547 MW; 0F5B41342A7020DA CRC64;
MWRRVASLSP LVSRSKPSKL SQEACTFKIW ESFSSESQVP TPSKVAPFIT FVLGGPGSGK
GTQCAKIVEE FGFTHISAGD LLRREIASNS AYGSVILSTI REGKIVPSQV TVQLIRKEME
SSDNDKFLID GFPRTSSNLQ IGREPNVVLF FDCPEREMVK RVLNRNQGRV DDNIDTIKKR
LEIFDELNWP VINHYSMTGK LHKINAVGTV DDIFEKFQKM VTTFQPLSFH TAKLSVCTSS
KSKKNKKQKQ LHQNQNTNSL SFPKSTPTPL IIYHKPSAQT KLQALDAVVK DLEASVDKGV
NVDTQTFASL LEICYQLEAM KYCHRVHKLI PRSLLRRNVG LSSKLLRLYA ASGRMEEAHK
VFDEMPKRDA SAFAWNALIS GYAELGLYED AMALYFQMEE EGVEPDRFTF PRVLKACGGI
GFIQIGEAVH RHVVRSGLLN DRFVLNALVD MYAKCGDIVK ARKVFDKISS RDKVSWNTML
TSYMRHGVLL QALDIFRQMF DEGYQPDSVS ISTILAAVQS LQLVVQIHGW VIRMGVEWNL
SIANALIAAY SKHHELNRAR WLFSHMPERD VVTWNTIISA HSKSREALLY FDQMEKDGAL
PDSITFVSIL SACANLGLVK DGQRLYSVMK NRYRISPIME HYACMVNLYG RSGRIKEAYG
IITDGMEFEA GPTVWGALLY ACYLHSNVDI GEVAAEKLFD LEPDNEYNFE LLMMIYGNVG
RLEDVERVRL MMMERGLDS
//
