ID   A0A498KPJ8_MALDO        Unreviewed;       366 AA.
AC   A0A498KPJ8;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN   ORFNames=DVH24_022498 {ECO:0000313|EMBL:RXI08354.1};
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI08354.1, ECO:0000313|Proteomes:UP000290289};
RN   [1] {ECO:0000313|EMBL:RXI08354.1, ECO:0000313|Proteomes:UP000290289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC   TISSUE=Young leaf {ECO:0000313|EMBL:RXI08354.1};
RA   Hu J.;
RT   "A high-quality apple genome assembly.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIPP family.
CC       {ECO:0000256|ARBA:ARBA00024045}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXI08354.1}.
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DR   EMBL; RDQH01000327; RXI08354.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498KPJ8; -.
DR   Proteomes; UP000290289; Chromosome 1.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   Gene3D; 3.30.70.100; -; 3.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   PANTHER; PTHR45811; COPPER TRANSPORT PROTEIN FAMILY-RELATED; 1.
DR   PANTHER; PTHR45811:SF80; HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 12; 1.
DR   Pfam; PF00403; HMA; 3.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 3.
DR   PROSITE; PS50846; HMA_2; 3.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000290289}.
FT   DOMAIN          1..68
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          122..189
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          243..310
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   REGION          68..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  41397 MW;  9E937BE8529E0C80 CRC64;
     MKKVVLKLEL YDEKCKKKVM RAVSGLEGLD SISMDMKDKK LTATGDIDPV HLVGRLRKLC
     RTEIVSVGPA KEEKKKEEPK KEEPKKKDPK DEMLELMKAY PALYPPMPAY YYVRSSEEDP
     NACKVVLKLE LHDEKGKKKA MRAVSGLEGL DSISMDMKDK KLTVTGDIDP VDLVGRLRKL
     CRTEIVSVGP AKEEKKKEEP KKEETKKKDP KDEMAELIKA YQAHCPPMPA YYYVKSSEED
     PNACKVVLKL ELHDEKGKKK AMRAVSGLEG LDSISMDMKD KKLTVTGDID PVDLVGRLRK
     LCRAEIVSVG PAKEEKKKEE PKKEETKPKD PKDQMAELIK AYQAYCPPMP AYYYVKSSEE
     DPSACI
//