ID A0A498KQ52_MALDO Unreviewed; 801 AA.
AC A0A498KQ52;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=CBS domain-containing protein {ECO:0000259|SMART:SM00116};
GN ORFNames=DVH24_023392 {ECO:0000313|EMBL:RXI09231.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:RXI09231.1, ECO:0000313|Proteomes:UP000290289};
RN [1] {ECO:0000313|EMBL:RXI09231.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXI09231.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|ARBA:ARBA00009476}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXI09231.1}.
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DR EMBL; RDQH01000327; RXI09231.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498KQ52; -.
DR STRING; 3750.A0A498KQ52; -.
DR Proteomes; UP000290289; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002251; Cl_channel_pln.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF165; CHLORIDE CHANNEL PROTEIN CLC-C; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01120; CLCHANNELPLT.
DR SMART; SM00116; CBS; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 87..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 604..657
FT /note="CBS"
FT /evidence="ECO:0000259|SMART:SM00116"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 86680 MW; DDDB73FB6F34B48B CRC64;
MMNEENGSSS SSSSSLVSDD GGDIENLDLL DGRRRTCSQP LLSKRKNTTS QIAIVGSNLC
SIESLDYEMF ENEIFRQDWR SAKKVQVFQY VVLKWAFALL IGIVTGLVGF FNNIAVENIA
GFKLLLTTAL MSDKKYYKAF AAYAAINVAL AAAAAALCAF IAPAAAGSGI PEVKAYLNGV
DAHSILAPST LFVKIFGSIL GVSAGFVVGK EGPMVHTGAC IASFLGQGGS RKYHLTWSWL
RYFKNDCDRR DLITCGAAAG VAAAFRAPVG GVLFALEEAA SWWRSALLWR TFFTTAVVAI
VLRGFIQYCT TGNCGLFGEG GLIMYDVSAA GATYSGPDIL AVLFLGTVGG ILGSIYNYFV
NKVIRTYSII HEKGAAPKIL LVITIALLTS CLSYGLPWFA ECQPCPTDES VSCPTVGKSG
NYKSFNCPSG YYNDLASLFL NTNDDAIRNL FSTSTKKEFH ISSLFIFFAA IYCLGIITYG
IAIPSGLFIP VILAGACYGR LVGRLFESIS TLDTGLFALL GAASFLGGTM RMTVSLCIIL
LELTNDLLLL PLVMLVLLIS KTVADNFNKG IYDQIVKIKG LPYLEAHAEP YMRQLVTADV
ATGPLVTFSG IEKVGRILDA LRTTGHNGFP VIDEPPFSDA PELCGLVLRS HLLILLKGKV
FSRERVVCEE EILGRFAAFN FAKAGSGKGI KVEDLDIEEE EMDMYVDLHP ITNASPYTVV
ETMSLAKAAI LFRQLGLRHL CLVPKSQGVS CSPPLPWSLF LCSLVQVKQA IRPPIVGILT
RHDFMPEHIL GLYPHIKAHK S
//
