ID   A0A498L3R0_LABRO        Unreviewed;       558 AA.
AC   A0A498L3R0;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Bifunctional coenzyme A synthase {ECO:0000313|EMBL:RXN02728.1};
GN   ORFNames=ROHU_035847 {ECO:0000313|EMBL:RXN02728.1}, ROHU_036592
GN   {ECO:0000313|EMBL:RXN24701.1};
OS   Labeo rohita (Indian major carp) (Cyprinus rohita).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Labeoninae; Labeonini; Labeo.
OX   NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN02728.1, ECO:0000313|Proteomes:UP000290572};
RN   [1] {ECO:0000313|EMBL:RXN02728.1, ECO:0000313|Proteomes:UP000290572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN02728.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:RXN02728.1};
RA   Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA   Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA   Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA   Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA   Shah T.M., Rai A., Jena J.K.;
RT   "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXN02728.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QBIY01013496; RXN02728.1; -; Genomic_DNA.
DR   EMBL; QBIY01012521; RXN24701.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498L3R0; -.
DR   STRING; 84645.A0A498L3R0; -.
DR   Proteomes; UP000290572; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:InterPro.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.
DR   CDD; cd02022; DPCK; 1.
DR   CDD; cd02164; PPAT_CoAS; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR   NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR   PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR   Pfam; PF01121; CoaE; 1.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A498L3R0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..558
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033827683"
FT   DOMAIN          186..330
FT                   /note="Cytidyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01467"
SQ   SEQUENCE   558 AA;  61687 MW;  3627AC80AF4F564D CRC64;
     MSMFSTGILV LTSPLHVLPL RIAPVLTSAA QVVERTLYVH LHPGLNLGTG GQARPVYIPP
     VVDLCTLISR LYSNAADICG HLDVRVLLSN IRSQPATLSG SSGPFPTPQK LSHSPEVVLT
     DFPIQDSGQS SLVTQCLQKY AGHCYVCNPS LSSVLLHPGL KEVEEDDDGG GRDVQLKPLE
     TFSDVVVGGT FDRLHGAHKT LLNTSCLMAN RRFVIGVCDR ELLKNKVLKE LIEPYDQRVE
     KLQDFLNDVK PSIKYEIVPL SDPFGPSISD PELQCIVVSE ETRKGGEAVN RKRLENGLAE
     LVLYEIQLLK DAHHADIEEE KISSSSLRTR LLGTLLKPPS LQPDLPLDPY VIGLTGGSGS
     GKSSIAHRLE GLGAVRIDCD QLGHEAYLPG TSAYHKVIQE FGSDILNEDK TINRRVLGGK
     VFGNQERLKA LTDIVWPEIA SLVKKRIKQA KEQGKHVCVV DAAVLLEAGW TYLVHEVWVA
     TIPEEEAVKR IVQRDGVKEE DALRRLKSQW PNAKLIEHAN VVLCTLWEPD VTQRQVSKAW
     NLLQQRIQKR QEITRSSL
//