ID A0A498L6E0_LABRO Unreviewed; 178 AA.
AC A0A498L6E0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=diphosphoinositol-polyphosphate diphosphatase {ECO:0000256|ARBA:ARBA00012527};
DE EC=3.6.1.52 {ECO:0000256|ARBA:ARBA00012527};
GN ORFNames=ROHU_034368 {ECO:0000313|EMBL:RXN03658.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN03658.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN03658.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN03658.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN03658.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol
CC polyphosphate + phosphate.; EC=3.6.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00033994};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. DIPP subfamily.
CC {ECO:0000256|ARBA:ARBA00008266}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN03658.1}.
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DR EMBL; QBIY01013473; RXN03658.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498L6E0; -.
DR STRING; 84645.A0A498L6E0; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR CDD; cd04666; Nudix_Hydrolase_9; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR047198; DDP-like_NUDIX.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR12629; DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR12629:SF5; DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:RXN03658.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498L6E0};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 17..144
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 178 AA; 20052 MW; 7FE53112828CEE5C CRC64;
MMKLKSNQTR TYDGDGYKKR AACLCFRNET EQEVLLVSSS RYPDKWIVPG GGMEPEEEPN
VAAAREVCEE AGVKGTLGRL VGIFENRDRK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF
KIEDAIEVLQ CHKPVQATYF EALQEGCLNS NGTPLVATIG GDLSPTYSIN QSSVSDIR
//
