ID A0A498L6P1_LABRO Unreviewed; 840 AA.
AC A0A498L6P1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Electroneutral sodium bicarbonate exchanger 1-like isoform X1 {ECO:0000313|EMBL:RXN03768.1};
GN ORFNames=ROHU_013218 {ECO:0000313|EMBL:RXN03768.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN03768.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN03768.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN03768.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN03768.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN03768.1}.
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DR EMBL; QBIY01013469; RXN03768.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498L6P1; -.
DR STRING; 84645.A0A498L6P1; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF37; ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 2.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..298
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 344..419
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT DOMAIN 428..528
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 49..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..68
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 96467 MW; 66C85EF715734C1D CRC64;
MCKRKVSRPD EEAVVDHGGT SSVLNIHYEK EELEGHRTLF VGVRMPMGRQ SHRHHRPHSS
KHRRRAERMR AGSVAQEDIN TESTTTSHDL VLDHQEAAHE LDDSVRMKVR EALLKRHHHQ
SDKKRNNLLP MVKSLTDSGR RQSEPHHMDK AGPATSPQPL PTNPDMKIGA ADNGQMDLSK
VDTHFMKKIP TGAEASNVLV GELDFLERSI VAFVRLSPAV LLTGLTEVPI PTRFLFILLG
PDGKAQQYHE IGRSMATIMT DEIFHDVAYK AKDRSDLLAG IDEFLDQVTV LPPGEWDPSI
RIEPPKSVPS QEKRKMPGVP NGTVVPVEEE QHGEHHGPEL QRTGRDYELS YLSLRTCIGL
WTAFLCLILV ATDASSLVCY ITRFTEEAFA ALICLIFIYE ALEKLFHLGE LYPINRHADL
DKLTLAFLKL ETESAAPGEQ PRFLGIREQR MTGLGIFLLM GLSVFMTGAL QFIPMPVLYG
VFLYMGVSSL KGIQFFDRLK LFGMPAKHQP DFIYLRHVPL RKVHLFTLTQ LTCLVLLWVI
KTSPAAIVFP MMVLALVFIR KLLDFCFSKR ELSYLDDLMP ENKKKKLDDD SKKAERAFHG
RINDRGFPEV SHEGHMSIED LRNALQDETN VMQIMRDFKR LRRYYELKIL DYLTKPIPNY
PKPVELHISE VIHVTNYNGF NGIMQSEGFK AQGYDNEKFS WWSLKIDEES IKAAEERYLE
KVLPNRSQEQ KERHEKFLSQ YTTSPAFDTD KSRYGTFRFT FSLKELMEAY KEQMCGGQDP
VLREYKTVFY KQEIILYSIR QWFATDNSLF RRFCAAALHL YQPTGQSQKR LLGIQQQKGF
//