ID A0A498L9E8_LABRO Unreviewed; 2892 AA.
AC A0A498L9E8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=ROHU_034640 {ECO:0000313|EMBL:RXN03054.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN03054.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN03054.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN03054.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN03054.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN03054.1}.
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DR EMBL; QBIY01013490; RXN03054.1; -; Genomic_DNA.
DR STRING; 84645.A0A498L9E8; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd19497; RecA-like_ClpX; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR010603; Znf_CppX_C4.
DR PANTHER; PTHR48102:SF7; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48102; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08477; Roc; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51902; CLPX_ZB; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RXN03054.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RXN03054.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1203..1384
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT DOMAIN 1752..2000
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 2357..2410
FT /note="ClpX-type ZB"
FT /evidence="ECO:0000259|PROSITE:PS51902"
FT REGION 881..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2335..2367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2501..2523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2864..2892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2501..2517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1779
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2892 AA; 322145 MW; 0F0A3034C337C528 CRC64;
MADKEELGIR LKKLLVRLNL QEGKQLGTIV QIIQDLLFLS HTDHCVELFA DQNVHMPLML
VLSSHFNSKV QQVGWSLLCR LMEICPTTLD SLACPVENEF TEVHKQILKV LSMYPKDSKM
MMVGLRALSL LLKSGEIAMQ VLHEEEQDVF FLILEAMRSF NDKEEVQLQG CAALQLLLQR
VSDAHLVEFI ENKDHEVILN ALRRFMDSEN MVLQALRVLI PLAAPASNIE ILMSKPVKCY
SLLCQAMDMW LESEAIQVAG CCLLRKFTSE SYYNILVLNG VHKVAVKACV SYPENATVQT
DAFSCLSALA ECIVQNEGLD KEWNEEDEAK QKVLVKKVAT QVEEMLIWRE ACYTALERHA
DNATVQEAAC VALNSLLLHC NSSNHVELEG RMRALLLSHG IHVNIVVLMR KHESSSAVCE
SACKLLHILF QGARASLDDA ILILGQILIA LKTHNFIPEV QLEGLRASLV LLNPDRSLRE
HGTSVADPDT VDVSLRVLKN QCVLEGAHTV YLEALNRFIS SVEIQECGLG VLSALADSSG
AVDLMCQQGA IDTVLHTLQM FPQGRDVHYW GLSLLFHLIS KKKLSRMMVP VLASVLVSSI
RQHKEDTVML LKGFQVVWKL LDTCSSAAAW LQKEAFEKDI FQILRENMAD QCRDPLQGMS
CLCLSKMVAD SEIMYALLER ACEDGDVDMA ECLIQLGADI NKKTKSDSLI YQVCDRGAPL
ALLELLVSAG VHEQQLRGAL SVCIRRGDDP AVTLLLTRLG LDHTNNALCL GSFRLGQMKA
MWLSALLSER KTQSPVNKKK SKGQRLARQI LSIQRNKGFV GVGRLRSDAS TSEYFTDEES
DDSHVSLDES LAFMLDDMES DGSDGPSQGL LLFNDSPEVG RKPAWRHSRR RRANSEGCRG
DTNPSAPLHK RFNSHNTRGQ GFIESSTPGA FPLAVDKEPI RLLDLSGNEL GNLSCLMGMS
ALKQQIENLL RLDLSSNSLS EFPSVLCQNL RSLTRLDLQG NQLQSLPVEL LGLPALSTLN
VSRNCIGPLL LLDPTVRSPA LRQLNLSFNQ ITVFPFQLGQ AMDRLEELSL EGLRSVDMRN
NSISDLPGPS FWVSVNLREL MFSHNQISVL DLSGPAYKWA RLEKLHLSSN KLTEIPPQIG
MLEDLTSLDV SQNEGLRSFP DEMGKLVHLW DLPLDGLQLQ MNLKHIGNKT KDIIRFLQQR
LKKAVPYYRM KLIVVGSPRS GKSSLIHQLM KLKRSHWQSD QHTIGVSVRD WAIRNKDKRN
MLLNVWEFSG GEECSGFHPH FMSSRALYLV LYDLSKGSSE IDTIKPWLFN IKAVAGQSPV
IVVGTHADVC EERHLQECVL KLREELMSQP GFPVIKENHI LCACEESESI SRLRKAICKE
LIGFKIQSQP VMGQLIPDCY VELERRVLQE RSHVPTDFPV LRHSRLLEII QETQLQLEEG
ELPHAIHFLS EAGVLLHFDD PVLQLKDLYF IDPQWLCNII SQTLTLRSTG PWDGTRGVMQ
RTTVEKFLNK SRCFPMDHLT QFFKLLEKFQ IALPFGDDQL LIPSSLSDHR PVIELPHCEN
SEVIVRLYEM PYFPMGYWPR QISRLLEVSA YLLYGKEKAL RPNRIYWRKG IYLSWSAEAY
CLVEALSLED NPASFIKITV PCSRKGCVLF GQVVDHIDSL LEEWFPGLLA TDVHGAGETL
LKKWALYSFS DGQNCQKILL EDLLSKINAD GLLVNPEDPS CTLPISQISP DLVLSDQPSS
TILDPEQLEM ELSMEYMLGD GGFGSVYKAV YKNEEVAVKI FNKHASTLYV HRLVRQELAV
LGRLCHPSLV GLLAAGCNPH ILVMELAPCG SLDSLFEREN SSLSRKLQHR IALHVADGLR
YLHSSMIIYR DLKPHNILLF NLKTDAEVIA KITDYGIAQY CCSMGVRSSE GTPGFRAPEV
ARGNVIYNVQ ADVYSFGLLL YDLLTYGERI SDGMKFPSEF DEAAVQGKLP GFESLMRVCL
RENPQDRPTS AQEIDSSPIL CMVIVRAPGS CSDWLVAGTQ SGSLYIMDTI SAEVLHCLKS
VKDSVTSLYF HTHRHLKNYL LVGTADGSLI IYEDSVLKVK DGGPVKTLQV GDVNTPLMCI
GPFSQNQERR ELWAACGSRV FSLSVEYDMS RSIDTKPKHL YTLSPTKKPK AQSEDQSRQM
VPSSATVKAL LVQHSGTLWI GTKAGHILLV EVSSCQLLQT ISPHCHSIRC MGSVLLADSL
NRKNVILVLG RRQRMPQDQI KTQAPAEDSV LTVWNSSLPL EVRDLIRHYL VLNMSCSCGP
AVRVILKSVH KGFPRSRVQL FSHTRAVCDE VHLPPFVHVR LFSQTAVCFA SKDGTTRDGD
GGKKGVSEAG GKRASGAGGS GKGGSQLRCP KCGDPCTHVE TFVSSTRFVK CEKCHHFFVV
LSEADSKKGL NKEADSSEHV KFALAQKPPP PPKKIYAYLD KYVVGQSYAK KVLAVAVYNH
YKRIYNNLPA AGRQQAETEK QSSLSPRELL QIAGINPHGN ALGASVQQQT NQQAPQDKRG
RDVLDSAPTD IKLEKSNIVL LGPTGSGKTL LAQTLAKCLD VPFAICDCTT LTQAGYVGED
IESVIAKLLQ DANYSVEKAQ QGIVFLDEVD KIGSVPGIHQ LRDVGGEGVQ QGLLKLLEGT
IVNVPEKNSR KLRGETVQVD TTNILFVASG AFNGLDRIIS RRKNEKYVVL SSYHLQYLGF
GTPSNLGKGR RAAAAADLAN SSGNEMDAMA EIEEKDRLLR HVEARDLIEF GMIPEFVGRL
PVVVPLHSLD EEMLVQILTE PRNAVVPQYQ ALFSMDKCEL NVTPEALRAI ARFALERKTG
ARGLRSIMEK LLLEPMFEVP QSDIIAVELT KEVVQGKCGP RYIRAPPKET EEEFDSASEE
DNWPRHADAA NN
//