ID A0A498LA07_LABRO Unreviewed; 1137 AA.
AC A0A498LA07;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=ROHU_012817 {ECO:0000313|EMBL:RXN05049.1}, ROHU_030632
GN {ECO:0000313|EMBL:RXN10562.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN05049.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN05049.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN05049.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN05049.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN05049.1}.
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DR EMBL; QBIY01013423; RXN05049.1; -; Genomic_DNA.
DR EMBL; QBIY01013198; RXN10562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LA07; -.
DR STRING; 84645.A0A498LA07; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 12.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 8.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 13.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 988..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..188
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 189..222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 255..293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 333..369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 371..407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 409..444
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 446..482
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 484..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 549..586
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 588..624
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 626..662
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 664..700
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 703..739
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 741..777
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1105..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 146..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 159..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 179..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 212..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 283..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 321..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 359..368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 397..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 413..423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 434..443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 472..481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 510..519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 576..585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 614..623
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 652..661
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 690..699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 729..738
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 767..776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1137 AA; 124762 MW; B20C0C7FE28A826F CRC64;
MQNANGELQN GSCCDGEKNP VDRKCTRDEC DTYFKVCLKE YQSRVSAAGA CSFGTGSTPV
LGGNKFSTKG TRSEKSRIVL PFSFAWPRSY TLIVEALDFN NDTASESVKL IEKAYHSGMI
NPNLQWQRLT HNGPIAQFEY QIRVTCDEHY YGFGCNKFCR PRDEFFGHYT CDQNGNKTCL
EGWTGPDCNT AICRQGCSTE HGSCKQPGGC KCLYGWQGPY CDKCIPHPGC VHGTCVEPWQ
CLCDTNWGGQ LCDKDLNYCG THQPCLNGGT CSNTGPDKYQ CSCEDGYSGV NCERAEHACL
SNPCANGGTC KETSQGYECH CAVGWSGPSC EINVDDCTPN PCKHGGTCQD LVNGFKCTCP
PHWTGKMCLI DANECEDKPC VNAKSCHNLI GGYFCECLPG WTGQNCDINI NDCQGQCLNG
GTCKDLVNGY RCHCPPGYSG EHCEKDVDEC ASSPCLNGGR CQDEVNGFQC LCPAGFSGQL
CQLDIDYCQP NPCQNGAQCF NLASDYICKC PDDYEGKNCS HLKDHCRTTS CQVIDSCTVA
VASNSTPEGV RYISSNVCGP HGRCRSQAGG QFTCECQEGF RGTYCHENIN DCESNPCRNG
GTCIDKVNVY QCICADGWEG AHCEINIDDC SLNPCLNKGA CQDLVNDFYC ECENGWKGKT
CHSRDSQCDE ATCNNGGTCH DEGDIFKCKC SPGWEGATCN IAKNSSCLPN PCENGGTCVV
NGDSFTCVCK EGWEGSTCTE NINECQSSPC AIGSTCVDEI NGYRCLCPPG RTGPECQEVI
GRPCIANGQV TADGAKWEED CNNCQCQNGK IHCTMMWCGP KSCRAGKSRT GCPAGQSCVP
IKEEHCFVKP CPSLGECWPP APPQPSKCHA SLSYQDDSCA NITFTFNKEN MPQGLSVEHV
CNELRHWYLL KNLTAEYAVS ITCEPSSSAS NEIHVSISTE EPRSDRNPIK DITGQIFDLV
NKHNGNSTII KAITGVRVHQ TPSPKTDYLV PLLSSIFIVL WILALASAFL WCIHRRRKQN
THSNATTSAT EDNTTNNVRE QLNQIKNPIE KHAAHGVAIK DYEGKNSIIA KIRTHNSEVE
EEEMDKHLQK ARFTKQPAYT LVEREERAPN KNPNWTNKQD NRDLETAQSL NRMEYIV
//
