ID A0A498LAQ3_LABRO Unreviewed; 1083 AA.
AC A0A498LAQ3;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Leucine-rich repeat and calponin homology domain-containing 2 isoform X2 {ECO:0000313|EMBL:RXN05258.1};
GN ORFNames=ROHU_033546 {ECO:0000313|EMBL:RXN05258.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN05258.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN05258.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN05258.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN05258.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN05258.1}.
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DR EMBL; QBIY01013413; RXN05258.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LAQ3; -.
DR STRING; 84645.A0A498LAQ3; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF14; LEUCINE-RICH REPEAT AND CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 2 ISOFORM X1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00033; CH; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1024..1048
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 577..692
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 911..1014
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 298..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1083 AA; 122451 MW; 68096AFD7C268D90 CRC64;
MKMAASQGAV GPAAALQSQH YPNVAHWNPG VIQQQQHPLH TARSLERALE DAVCSGMLNI
SGRKLRDYPG LNYDLTDTTQ ADLSKNRFCE IPPEVCMFAP LESLNLYHNC IKVVPEAIIN
LQMLTYLNIS RNQLSVLPKF LFNLPLKVLV VSNNKLLSIP EEIGKAKDLM ELDISCNEIQ
VLPVQMGKLL ALRELNIRRN CLQVLPDELS DLPLIRLDFS CNKITEIPIS YRKLKQLQHI
VLDNNPMQSP PAQICLKGKI HIFKYLNLQA CRLDKKPDTL DLPSLGKRCL PQQLTDSMED
FYPSKNHGPD SGIGSDNGDK RLSTTEPSDD DTMSLHSQVS ETARADAHIL LTKLDSNKDQ
DPYDFIDPNP DEEATLSEGD LQHNAPYVSC IKELERVLKT HQSKDKENWK EESGSEKEQL
AEEDEDDLKE VLDLRKIAVQ LLQQEQQNSA SLDEGSSSAS GLSGQPSSSC SFDGSLKSES
SDSEPRWPEV PPVLNQNEDR RRNKYLRKDY LKYKCQSARR NSSGNDNDCE EGMRSNDFTT
TLTVFGLKPR SAFSRGNRQD FSSTDPSFTM RRKMEHLREE MEQIRLLRQN LESRLKVLLP
DDVGAALMDG VVLCHLANHI RPRSVASIHV PSPAVPKLSM AKCRRNVENF LDACKKLGVP
QTLIIALQKN MLLLDKVPAW LSAFTLLLLT QEPVSTSEVT ACGVAVDPPA NIEISDPGFL
GYISIHWTRP AGLQNLTDCT VRYQLRYYDT YEERWRSVRT VKLTYAAQFD LEKPVKLRIL
TLLKCACTNG TEVQGKETEW AYTPEPTGVA GSRIRDFHCV YYGKEYMECT WESGPVQPPN
SQHYLYYWHR EMDETKECPE YIMSSEGRRG CRFPRESLLE FSKFNLCVNG SSPAGSLRTA
YFSIEVQNHV KPAVVSSVHV SETDEGLKLD WSPPSGQVPE HCLEYEVESS TMMENGKEEQ
ERMVLQNLAD TSYGVPRQAE SQKTCFRIRS KVNTYCADEG FWSNWSQTKC TADTETQDIP
TWKYLGLVGL VVIGIAGVII LCLSLWILRK ICIKKISKKD VLYTLYKEKV NETMPTILSP
IFK
//
