ID A0A498LBD8_LABRO Unreviewed; 172 AA.
AC A0A498LBD8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 28-JUN-2023, entry version 13.
DE RecName: Full=Gremlin {ECO:0000256|PIRNR:PIRNR037254};
GN ORFNames=ROHU_012657 {ECO:0000313|EMBL:RXN05609.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN05609.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN05609.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN05609.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN05609.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR037254}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC ECO:0000256|PIRNR:PIRNR037254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN05609.1}.
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DR EMBL; QBIY01013397; RXN05609.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LBD8; -.
DR STRING; 84645.A0A498LBD8; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR017159; Gremlin-1/2.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF3; GREMLIN-1; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF037254; Gremlin_precursor; 1.
DR SMART; SM00041; CT; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR037254};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR037254-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Secreted {ECO:0000256|PIRNR:PIRNR037254};
KW Signal {ECO:0000256|PIRNR:PIRNR037254}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT CHAIN 25..172
FT /note="Gremlin"
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT /id="PRO_5019622211"
FT DOMAIN 84..171
FT /note="CTCK"
FT /evidence="ECO:0000259|SMART:SM00041"
FT REGION 27..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 82..132
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 96..146
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 106..164
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 110..166
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
SQ SEQUENCE 172 AA; 19880 MW; BC1E926A5CA8E1C5 CRC64;
MASSARILCA LLFVWVLLST PTECKRNRGA IPHPDKSNPN ESDQQQPASG SRGRSRGSEE
VLESSQEALH VTERRYLKRD WCKTQPLKQT IHEEGCISRT IINRFCYGQC NSFYIPRHVR
REEGAFQSCS FCKPKRFTTM TFTLNCPDQQ PPTRKKRVQR VKQCRCISIE LD
//
