ID A0A498LCT6_LABRO Unreviewed; 731 AA.
AC A0A498LCT6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN ORFNames=ROHU_033027 {ECO:0000313|EMBL:RXN06058.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN06058.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN06058.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN06058.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN06058.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN06058.1}.
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DR EMBL; QBIY01013380; RXN06058.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LCT6; -.
DR STRING; 84645.A0A498LCT6; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF10; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 556..716
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
SQ SEQUENCE 731 AA; 82820 MW; 343ECA2A1629970D CRC64;
MKETLQDLVC RSVISPVTET TEWVNSLAIT EKKNGSLRVC LDPRDLNKAI KRQHHSIPTP
DEVCSNLAGK SIFTILDEKD GYWQIKLDEP SSKLCTFNSP WGRYCFRRLP FGIRSASEVF
QQKNCETFGD IQGVHIIADD MIIAASSEQE HDEILDKVME RAKAAKMRFN GEKIQFKVKT
VKYMGHIITP EGLRPDEAKV KAITDMPPPE DKQALQRLLG MTKYLAQYIP KEASLTAPLR
QLLRKDAVWQ WNPHHSTASE NLKSALTKAP VLRFYDHKKP LTIQADSSKD GLGACLLQEG
HPVCYASRAL TDTEQRYAQI EKELLAILFA ARKFHQYRYG RTVMVQSDHK PLENIMQKQL
CKAPARLQRM LLQLQKYELN IAYTPGKHMH IADMLSRATV GSEADDSGDL YDEKVVHGLE
ATDALSPQTL QQLKEATVAD QVLQDLCEKV ETGWPQRRRS VNSNLHSYWP MRHKISVQNG
IVMAGDKIII PHSFRKAILE KLHIAHQGMQ RTKAKARKSL YWPGMAQDIE MMVEKCAPCQ
QLQPWQQKEP LITHDVPELP WMKVGADIFE LRGQSYLLLV DYLTKYPEVL NIPDKSAHTV
IQKMKSVFAR HGIPKELVSD NVPFASYEMQ AFAALWDVKL TFSSPGYPQS NGLAERAIKT
VKHALKKALQ TGTDPHLVLL SLRNTPVTGL NESPAQMLMG RVLRSTIPCS SAVLQQSTPQ
HIHKRLVDLQ S
//
