ID A0A498LF33_LABRO Unreviewed; 650 AA.
AC A0A498LF33;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=High affinity cationic amino acid transporter 1-like isoform X1 {ECO:0000313|EMBL:RXN06830.1};
GN ORFNames=ROHU_006444 {ECO:0000313|EMBL:RXN23137.1}, ROHU_012111
GN {ECO:0000313|EMBL:RXN06830.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN06830.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN06830.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN06830.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN06830.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00034423};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935,
CC ChEBI:CHEBI:32551; Evidence={ECO:0000256|ARBA:ARBA00034422};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000256|ARBA:ARBA00034450};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000256|ARBA:ARBA00008572}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN06830.1}.
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DR EMBL; QBIY01013357; RXN06830.1; -; Genomic_DNA.
DR EMBL; QBIY01012567; RXN23137.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LF33; -.
DR STRING; 84645.A0A498LF33; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR NCBIfam; TIGR00906; 2A0303; 1.
DR PANTHER; PTHR43243:SF28; HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 552..602
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
SQ SEQUENCE 650 AA; 71077 MW; 5C245217330D0CB7 CRC64;
MMVLKKLLRF GKQLLRVKVV DCNSEESRLS RCLNTFDLVA LGVGSTLGAG VYVLAGAVAR
ENAGPAIVLS FLIAALASVL AGLCYAEFGA RVPKTGSAYL YSYVTVGELW AFITGWNLIL
SYVIGTSSVA RAWSATFDEL IGKHIEHFCR QYMSMNAPGI LAEYPDMFSV FIILTLTGLL
AFGVKESAMV NKVFTCINIL VLLFMVVSGL VKGTLKNWHL DPDEILNETN STLNSTQPLP
SEEILGEGGF MPFGFTGVLS GAATCFYAFV GFDCIATTGE EVKNPQRAIP IGIVTSLLIC
FVAYFGVSAA LTMMMPYYML DKNSPLPVAF KYVGWEGATY AVAVGSLCAL STSLLGAMFP
MPRVIWAMAD DGLLFKFMTG INERTKTPIH ATITAGFAAA IMAFLFDLKD LVDLMSIGTL
LAYTLVAACV LVLRYQPEQF SQTYHIASTH DEMEMSETIS TPSMGILPGI EERLSFKTLF
FPDITEPSNL SGFTVNICAS LLGLLIFSFS LLAVLGGSAM WSIVTLSVLF SMCVIITFII
WRQPESKTKL SFKVPLLPFI PVVSMFVNVY LMMQLDRGTW IRFAIWMSLG LVIYFGYGIW
HSTEASLVHS SMDEELNVYK PACSLNRDSV TPEKEAFLCN GSRVDEDGDL
//