ID A0A498LFF0_LABRO Unreviewed; 773 AA.
AC A0A498LFF0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H3 {ECO:0000256|ARBA:ARBA00039924};
GN ORFNames=ROHU_012191 {ECO:0000313|EMBL:RXN06910.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN06910.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN06910.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN06910.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN06910.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a carrier of hyaluronan in serum or as a binding
CC protein between hyaluronan and other matrix protein, including those on
CC cell surfaces in tissues to regulate the localization, synthesis and
CC degradation of hyaluronan which are essential to cells undergoing
CC biological processes. {ECO:0000256|ARBA:ARBA00037051}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN06910.1}.
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DR EMBL; QBIY01013357; RXN06910.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LFF0; -.
DR STRING; 84645.A0A498LFF0; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF115; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..95
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 183..362
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 773 AA; 87371 MW; 557AFF5124A0199D CRC64;
MTTKALNRAN ASQVLFEVDL PKTAFITSFS IEIEGRIYVS EVREKEQARQ QYESAVSSGQ
TAGLVKASGR NMEKFSVSVN IAPQSRVTFT LTYEELLKRR VGSYEIMIGV RPKQLVQNFE
IVVDIYEPNG IAFVDVNSTF ITNELLPLVE KTVTDKKAHV YFSPTLDQQK KCSACEETLI
DGDLIIKYDV NHPQDIGEIQ TREALMTILS ELDEDDYFGL VTFDDTIESW KPFLSKATPE
NVTEAKEFVE TIEARHLTDI NKGLMYAVEM LTSEKSDFFP DMSMIILLTD GRPSAGEQDL
SKIQENVRSA INGSMSLFCL GFGYDVDYGL LDTLAKQNDG LARRVYEASD AVLQLQGFYD
EVATPLLLEV NLNYPGNAVT DLTQSHFRQF FKGSEIVVAG RLQELETDTI QTQVSAQGLE
DQFVIGGLAI TEEWDSVFPD QEYVFGDFTE RLWAYLTIQQ LLDKRETCSP EDKENITAEA
LDLSLRYNFV TPLTSMVVTK PETEDDEDET LIADKLTEEQ REDITEPVDG DPHFIIELPD
QNDALCFNID EKPGTIFNLV KDPLTGIVVN GQIIGDKKLI PGSKMHTYFG RFGIVHEKLG
IRLMVSTKEI SVSEDGKQLD FSWTNNKTLN GLNMDLQVIK DRSLTVTLKN SVKFLIILHK
IWKKHPYHQD YLGFYTLDSH LFSSNVHGLL GQFYHGVKFE VSDLFPGMDP DKQDANMFVK
GHKLTVTRGW KRDFRQDVKN GENVPCWFIH NNGTGLLDGV HTDYIVSSLL QTI
//