ID A0A498LJD0_LABRO Unreviewed; 747 AA.
AC A0A498LJD0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Cadherin-6 {ECO:0000256|ARBA:ARBA00041042};
GN ORFNames=ROHU_033232 {ECO:0000313|EMBL:RXN05737.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN05737.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN05737.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN05737.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN05737.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types. {ECO:0000256|ARBA:ARBA00037319}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN05737.1}.
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DR EMBL; QBIY01013392; RXN05737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LJD0; -.
DR STRING; 84645.A0A498LJD0; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF322; CADHERIN-6; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 562..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..119
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 120..228
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 229..343
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 344..448
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 448..549
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 747 AA; 83512 MW; 35E15BAC67F704BD CRC64;
MKGDKLVLHR SKRDWMWRQF FLSEEYTGSN YQYVGKLRSD KDRGDGTARY VLSGEGAGTI
FRIDEKSGDL HATQRLDREE KSSYTLQAQA FNKITGLPLE PATEFIVKIH DINDNEPKFT
KAVYTASVPE MSDVGTFVIE VNATDADDAT YGNSAKLVYS ILQGQPYFSV EPETGIVRIA
LSNMDREVRK EYQVVIQAKD MAGQMGGLSG TAMVNVTLTD VNDSPPRFAY SSYHLSTYES
AEIGSTVGRI KANDGDEGEN AEMKYKIVDG DGKDYLDIIT DEITQEGVIV VKKKMDYESK
RIYTVKVEVT NTHQDPNFAD LGPFLDTAIV KVTAKDVDEP PVFSRPQYVF EVNEDTPKGI
AIGTISAWDP DATHYPIQYA IDQHTDPERL YHIDPKNGSI TILKSLDREV SKWHNISVLA
SEINNPHQRS RVPVLIKVLD VNDNAPEFAM IYETFVCENV KAGQLIQTIS AIDTDDPLVG
HKFVFSLSSM NPNFTIFDNE DNTARILTRR SGFNRREMSV YYLPVVISDS DYPIQSSTST
LTIRVCSCDA TGNMRSCSVD ALLLSAGLST GALVAILLCI LILLMIVVLF SALKKQRRKE
PLIISKEDVR DNVVSYNDEG GGEEDTQAFD IGTLRHPEVI ESNKLRRDII PEMLFPYHRP
SPMKECADVR DFIISRLQEN DTDPFAPPYD SLATYAYEGN GSIAESLSSL ESSVTEADHE
YDYLSNWGPQ FKKLADMYIG KDTGVAN
//
