ID A0A498LKV4_LABRO Unreviewed; 847 AA.
AC A0A498LKV4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN ORFNames=ROHU_035395 {ECO:0000313|EMBL:RXN08173.1}, ROHU_036427
GN {ECO:0000313|EMBL:RXN27291.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN08173.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN08173.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN08173.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN08173.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN08173.1}.
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DR EMBL; QBIY01013329; RXN08173.1; -; Genomic_DNA.
DR EMBL; QBIY01012047; RXN27291.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LKV4; -.
DR STRING; 84645.A0A498LKV4; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 392..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 437..459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 606..629
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 663..683
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 762..784
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 63..261
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 295..807
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 847 AA; 98756 MW; 19CA51FB7EF6E7AF CRC64;
MSEAEDNDIH ELDSEIEEGD VEMNLMTDVV YSEELPTYKS MPKGQAVPKV DRAEFNGNPD
SLFFNDGKRR IDFVLVYEDE SKNVSEKKRS IVRRRVKDEK LIYVKVHMPF EVLCTYAEVL
HIKLPIQPND LAPQSSAYSC FTRHFYPSED VIAKEPDFFT APFRKDQLNC FYVKDKEQFF
MPATRSRMAY YILSRAPYEV KGNVKKFGMN KLLDGGVYKA AYPLHDCRFN VKSKEPDCPN
ERFLLYNEWA HPKSFYKMQP LDLISKEVCD PQIGGEIIMC PQCDLDCPYW RLNTTCESSK
RLCIFDNFGT LVFAIFMSVW VTLFLEFWKR YQAELEHDWD TVEFLQQEEQ PRPEYEAKCV
YERLNPVTQE KEKVPYTACG KCMRVSCGIG TVLFWVLLII ASVVGVIVYR LAMFITFSLK
LRSDLKYTKE LEPFKEYVTP QMATSITASI ISFIIIMVLN NVYEKVAIWI TDFELPRTKT
EYENSLTLKM FLFQFVNYYS SCFYIAFFKG KVVGYPGQPV YWFGAFRNEE CDPGGCLTEL
TAQLSIIMTG KAIWNNIQEV LLPWVKNLIF RHCTQVGSEK VIPRWEQDYQ LQPIGKLGLF
YEYLEMVIQF GFVTLFVASF PLAPLLALFN NLCEIRVDAW KITTQCRRVV PEKAQDIGAW
QPILQGIAIL AVATNAAIIA FTSDMIPRLV YYWAFSVSPY SDGSNHTMAG FINSSLSVFN
INDFSNMSRP DSMPYWFNNI TTCRYRDYRN PPGDPNQYEL NIYYWHVIAA KLAFMIVVEH
IVYFTKFMLS YMIPDVPEAL KEQIKRERYL TQVKLHESSI RHFKELMKPV ADNLQNEFEE
SELDLRL
//
