ID A0A498LM59_LABRO Unreviewed; 1178 AA.
AC A0A498LM59;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=ROHU_011253 {ECO:0000313|EMBL:RXN09111.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN09111.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN09111.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN09111.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN09111.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN09111.1}.
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DR EMBL; QBIY01013293; RXN09111.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LM59; -.
DR STRING; 84645.A0A498LM59; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 12.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 8.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 12.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 8.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 14.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1178
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019857169"
FT TRANSMEM 997..1022
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 186..230
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 231..264
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 297..335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 337..373
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 375..411
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 413..449
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 451..486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 488..524
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 526..562
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 589..628
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 630..666
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 668..704
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 706..742
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 750..786
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1029..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 188..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 201..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 221..230
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 254..263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 325..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 363..372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 401..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 439..448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 455..465
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 476..485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 514..523
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 552..561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 618..627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 656..665
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 694..703
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 732..741
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 776..785
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1178 AA; 128768 MW; 9EE4F4CAEFF6EF33 CRC64;
MILRRTPSFA VLALHVLLRC LWMRVCEASG HFEMQVLSMQ NLNGELQSGA CCDGGRVAAD
RTCTADECDT FFRVCLKEYQ SRVSSGGPCS YGSGSTPVIG GNTFSLKPLD NANDKSRIVL
PFSFAWPRSY TLIVEALDFN NDSSTGSING QVIEKAVQSG MINPNRQWQV LKHNGPVAQF
QYQIRVTCDE HYFGFGCNKF CRPRDDFFGH YTCDHNGNKT CLEGWAGPEC NTAICKQGCS
TEHGSCKVPG DCRCLYGWQG EYCDQCIPHP GCVHGTCVEP WQCLCDTNWG GQLCDKDLNT
CGTRQPCLNG GTCSNTGPDK YHCACPDGYS GQNCERADNA CLSEPCLNGG SCVESSQGFE
CQCAPGWTGP SCNINEDDCS PNPCNHSGVC VDLVDGFKCI CPVQWTGKTC LIDANECEEN
PCVNAHSCRN LIGGYFCECL PGWTGQNCDI NVNDCHGQCL NGGLCKDLVN GYRCLCAPGF
AGEHCERDVD ECASRPCLNG GRCQDAVNGF QCLCPPGFSG ATCQLDIDYC ESGPCQNGAQ
CFSLASDYYC KCPEDYEGKN CSQLKDHCLI TPCQVIDSCT VAVASNSTPG GMRLISSNVC
GPHGRCRSHA GGHFSCECQE GFTGTYCHEN INDCESSPCS NGGTCIDKIN AYQCICADGW
EGHNCESNID DCSMNPCRDR GVCRDLVNDF YCECENGWKG KTCHSRESQC DEATCNNGGT
CSDEGDSFKC MCAPGWEGAT CNIAKNSSCL PNPCENGATY NSGTCVDGDN WYRCECASGF
AGPDCRIITG RPCVVGGRIA VDGAKWTEDC NTCYCHRGIV SCTKLWCGPK PCRMLGSGRG
DCPLGQLCVP VRDEQCFVKP CSSQGECWSA HRPAVRARCH PESDCANVTF TFNKDTMPQG
VTVEQVCREL RHLYVAKNVS SEISISMSCE ISYAANNEIH VAIHVTEDGI HGRVPVKEIT
DSIIDLVSKH SANSSIIGSI AEVRVQRRQP QNPNVDYLVP LLVSIVTAIW VLALASVFLW
CVRHRRKQSS SPTAVNPATP YSMGSTEDNT VNNAREQLNQ IKNHIEKNAS NGSLPGKELH
CDDKNSVNAK IRTHFSESSR LAQEDSNKRL QKVRFPHQPA YMLVDRDDRL SANGTDTKNP
RWTNKRDNRD LESQHRGPDS QQRDLDAQHS LQKMEYIV
//
